A comparison of the induction of myeloid and lymphoid leukemias in x-radiated RF mice.
A comparison of the induction of myeloid and lymphoid leukemias in x-radiated RF mice.
复制标题
X 辐射 RF 小鼠中诱导骨髓性白血病和淋巴性白血病的比较。
作者：
A. Upton;F. F. Wolff;J. Furth;A. Kimball
总结1.在各种实验条件下研究了RF品系小鼠对辐射诱导的髓性白血病和淋巴瘤的易感性。2.虽然这两种疾病的诱发率与辐射剂量有关，但两种肿瘤的发病率与剂量之间的关系并不相同;在0-500 r. 3.在一定剂量的辐射分次照射中，白血病的诱发率随总剂量、每次照射剂量、照射间隔和所产生的白血病的血液学类型而变化。4.在照射身体其他部位时，屏蔽骨盆和下肢可大大抑制髓性白血病和淋巴瘤的诱发。5.卵巢切除术降低了女性对淋巴瘤诱导的敏感性，但卵巢切除术对淋巴瘤诱导的敏感性没有影响。男性比女性更易诱发骨髓性白血病，但在两种性别中，性腺切除术均未显著影响其易感性。在诱发淋巴瘤和髓性白血病的易感性方面的性别差异甚至在性腺切除后仍然存在。6.在照射前切除脾脏可大大降低诱导髓性白血病的敏感性，但不影响淋巴瘤的诱导。7.新生小鼠对诱导髓性白血病有抵抗力，尽管对淋巴瘤形成有易感性，而在6个月大时接受辐射的小鼠则相反。8.在照射前切除胸腺，消除了胸腺淋巴瘤的诱导，允许在胸腺外淋巴组织中诱导淋巴瘤，但不影响髓性白血病的形成。
Summary 1.The susceptibility of mice of the RF strain to radiation-induced myeloid leukemia and lymphomas was studied under a variety of experimental conditions. 2.Although the rate of induction of both diseases varied in relation to the dose of radiation, the relation between disease incidence and dose was not the same for both neoplasms; neither was it linear over the dosage range 0–500 r. 3.On fractionation of a given dose of radiation, the rate of induction of leukemia varied depending on the total dose, dose per exposure, interval between exposures, and hematologic type of leukemia produced. 4.Shielding of the pelvis and lower extremities during irradiation of the remainder of the body greatly inhibited the induction of myeloid leukemia as well as of lymphomas. 5.Susceptibility to lymphoma induction, which is higher in females than in males, was decreased by ovariectomy but was not affected by orchidectomy. Susceptibility to the induction of myeloid leukemia, which is higher in males than in females, was not significantly affected by gonadectomy in either sex. The sex differences in the susceptibility to induction of lymphomas and myeloid leukemia persisted even after removal of the gonads. 6.Removal of the spleen before irradiation greatly lowered susceptibility to the induction of myeloid leukemia but did not influence the induction of lymphomas. 7.Newborn mice were resistant to the induction of myeloid leukemia despite susceptibility to lymphoma formation, whereas the reverse was true of mice irradiated at 6 months of age. 8.Removal of the thymus before irradiation, which eliminated the induction of thymic lymphomas, permitted the induction of lymphomas in extrathymic lymphoid tissues but did not influence the formation of myeloid leukemia.