DIFFERENTIAL CONTRIBUTION OF AMYGDALA AND HIPPOCAMPUS TO CUED AND CONTEXTUAL FEAR CONDITIONING
DIFFERENTIAL CONTRIBUTION OF AMYGDALA AND HIPPOCAMPUS TO CUED AND CONTEXTUAL FEAR CONDITIONING
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DOI：
10.1037/0735-7044.106.2.274
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发表时间：
1992-04-01
影响因子：
1.9
通讯作者：
LEDOUX, JE
中科院分区：
文献类型：
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作者：
PHILLIPS, RG;LEDOUX, JE
在大鼠中检查了杏仁核和海马对提示的条件恐惧反应的贡献（一种与脚印配对的音调）和对背景（背景刺激在仪器中连续存在的背景刺激）在大鼠中检查了发生音调配对的设备）。在非手术控制中，对提示的反应更快，并且比对上下文刺激的反应更能抵抗灭绝。杏仁核的病变干扰了对提示和上下文的恐惧反应的条件，而海马的病变则干扰了环境的条件，但没有对提示。因此，杏仁核参与了对简单的，特定于模态的刺激以及对复杂的，多形的刺激的恐惧反应的调节，而海马只参与涉及复杂的多种多态事件的恐惧调节情况。这些发现表明，杏仁核具有关联作用，以及海马在恐惧条件中的感官继电器作用。
The contribution of the amygdala and hippocampus to the acquisition of conditioned fear responses to a cue (a tone paired with footshock) and to context (background stimuli continuously present in the apparatus in which tone-shock pairings occurred) was examined in rats. In unoperated controls, responses to the cue conditioned faster and were more resistant to extinction than were responses to contextual stimuli. Lesions of the amygdala interfered with the conditioning of fear responses to both the cue and the context, whereas lesions of the hippocampus interfered with conditioning to the context but not to the cue. The amygdala is thus involved in the conditioning of fear responses to simple, modality-specific conditioned stimuli as well as to complex, polymodal stimuli, whereas the hippocampus is only involved in fear conditioning situations involving complex, polymodal events. These findings suggest an associative role for the amygdala and a sensory relay role for the hippocampus in fear conditioning.