Iterative reconstruction based on median root prior in quantification of myocardial blood flow and oxygen metabolism.
Iterative reconstruction based on median root prior in quantification of myocardial blood flow and oxygen metabolism.
复制标题
基于中根先验的迭代重建对心肌血流量和氧代谢进行量化。
DOI：
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复制
发表时间：
1999
影响因子：
9.3
通讯作者：
J. Knuuti
中科院分区：
文献类型：
--
作者：
C. Katoh;U. Ruotsalainen;H. Laine;S. Alenius;H. Iida;P. Nuutila;J. Knuuti
未标记的
UNLABELLED
The aim of this study was to compare reproducibility and accuracy of two reconstruction methods in quantification of myocardial blood flow and oxygen metabolism with 15O-labeled tracers and PET. A new iterative Bayesian reconstruction method based on median root prior (MRP) was compared with filtered backprojection (FBP) reconstruction method, which is traditionally used for image reconstruction in PET studies.
METHODS
Regional myocardial blood flow (rMBF), oxygen extraction fraction (rOEF) and myocardial metabolic rate of oxygen consumption (rMMRO2) were quantified from images reconstructed in 27 subjects using both MRP and FBP methods. For each subject, regions of interest (ROIs) were drawn on the lateral, anterior and septal regions on four planes. To test reproducibility, the ROI drawing procedure was repeated. By using two sets of ROIs, variability was evaluated from images reconstructed with the MRP and the FBP methods.
RESULTS
Correlation coefficients of mean values of rMBF, rOEF and rMMRO2 were significantly higher in the images reconstructed with the MRP reconstruction method compared with the images reconstructed with the FBP method (rMBF: MRP r = 0.896 versus FBP r = 0.737, P < 0.001; rOEF: 0.915 versus 0.855, P < 0.001; rMMRO2: 0.954 versus 0.885, P < 0.001). Coefficient of variation for each parameter was significantly lower in MRP images than in FBP images (rMBF: MRP 23.5% +/- 11.3% versus FBP 30.1% +/- 14.7%, P < 0.001; rOEF: 21.0% +/- 11.1% versus 32.1% +/- 19.8%, P < 0.001; rMMRO2: 23.1% +/- 13.2% versus 30.3% +/- 19.1%, P < 0.001).
CONCLUSION
The MRP reconstruction method provides higher reproducibility and lower variability in the quantitative myocardial parameters when compared with the FBP method. This study shows that the new MRP reconstruction method improves accuracy and stability of clinical quantification of myocardial blood flow and oxygen metabolism with 15O and PET.
解剖学定义与基于生理学的区域定位的比较：对 PET-FDG 定量的影响。
DOI：
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发表时间：
1993
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Resnick,SM;Karp,JS;Turetsky,B;Gur,RE
通讯作者：
Gur,RE
临床接受者操作特征研究的结果，比较 FDG PET 研究中的滤波反投影和最大似然估计图像。
DOI：
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发表时间：
1993
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Llacer,J;Veklerov,E;Baxter,LR;Grafton,ST;Griffeth,LK;Hawkins,RA;Hoh,CK;Mazziotta,JC;Hoffman,EJ;Metz,CE
通讯作者：
Metz,CE
用于最大限度地减少定量心肌 PET 研究中分辨率失真的感兴趣区域策略。
DOI：
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发表时间：
1992
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Hutchins,GD;Caraher,JM;Raylman,RR
通讯作者：
Raylman,RR