An Electrochemical Biochip for Measuring Low Concentrations of Analytes With Adjustable Temporal Resolutions
An Electrochemical Biochip for Measuring Low Concentrations of Analytes With Adjustable Temporal Resolutions
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DOI：
10.1109/tbcas.2020.3009303
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发表时间：
2020-07
影响因子：
5.1
通讯作者：
Kae-Dyi You;Edoardo Cuniberto;Shao-Cheng Hsu;Bohan Wu;Zhujun Huang;Xiaochang Pei;D. Shahrjerdi
中科院分区：
文献类型：
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作者：
Kae-Dyi You;Edoardo Cuniberto;Shao-Cheng Hsu;Bohan Wu;Zhujun Huang;Xiaochang Pei;D. Shahrjerdi
由纳米石墨（NG）碳材料制成的电化学微型传感器可以提供高灵敏度，并支持在截然不同的时间分辨率下进行伏安法测量。在这里，我们利用 NG 微传感器的这些优势特性，实现了可配置的 CMOS 生物芯片，用于测量低浓度的生物分析物。特别是，生物芯片的核心是离散时间$\Delta \Sigma$调制器，可以根据传感实验的时间分辨率要求配置最佳功耗，同时提供$\approx$13有效位数所需的精度。我们通过使用晶体管物理模型开发一种设计方法来实现这一新功能，该方法允许调制器的工作区域在弱反转和强反转之间按需切换。我们通过在 100 ms 和 10 s 的时间分辨率下分别对浓度低至 50 nM 和 200 nM 的多巴胺进行体外测量，展示了这种可配置生物芯片的应用。
Electrochemical micro-sensors made of nano-graphitic (NG) carbon materials could offer high sensitivity and support voltammetry measurements at vastly different temporal resolutions. Here, we implement a configurable CMOS biochip for measuring low concentrations of bio-analytes by leveraging these advantageous features of NG micro-sensors. In particular, the core of the biochip is a discrete-time $\Delta \Sigma$ modulator, which can be configured for optimal power consumption according to the temporal resolution requirements of the sensing experiments while providing a required precision of $\approx$13 effective number of bits. We achieve this new functionality by developing a design methodology using the physical models of transistors, which allows the operating region of the modulator to be switched on-demand between weak and strong inversion. We show the application of this configurable biochip through in-vitro measurements of dopamine with concentrations as low as 50 nM and 200 nM at temporal resolutions of 100 ms and 10 s, respectively.