The September epidemic of asthma exacerbations in children: A search for etiology
The September epidemic of asthma exacerbations in children: A search for etiology
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DOI：
10.1016/j.jaci.2004.09.025
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发表时间：
2005-01-01
影响因子：
14.2
通讯作者：
Sears, MR
中科院分区：
文献类型：
--
作者：
Johnston, NW;Johnston, SL;Sears, MR
背景资料：在全球范围内，需要住院治疗的哮喘急性发作的可预测高峰出现在学生返校后，其中儿童发病率最高，病因不明。目的：我们希望确定9月份返校后需要急诊科治疗急性发作的哮喘儿童是否比同样严重的哮喘儿童更有可能存在呼吸道病毒，并且更不可能有控制药物的处方，需要紧急治疗。方法：2001年9月10日至30日期间，加拿大2个社区57名（60名）5至15岁哮喘儿童急诊室的病毒检测率和哮喘管理特征，与同期研究的157例年龄匹配的哮喘严重程度相当的志愿儿童进行比较结果：在52%的病例和29%的对照中检测到人类小核糖核酸病毒（P=.002），在62%的病例和41%的对照中检测到任何类型的病毒（P =.011）。病例不太可能接受控制性药物治疗（吸入性皮质类固醇，49%对85%; P
Background: Predictable peaks of asthma exacerbation requiring hospital treatment, of greatest magnitude in children and of uncertain etiology, occur globally after school returns.Objective: We wished to determine whether asthmatic children requiring emergency department treatment for exacerbations after school return in September were more likely to have respiratory viruses present and less likely to have prescriptions for control medications than children with equally severe asthma not requiring emergent treatment.Methods: Rates of viral detection and characteristics of asthma management in 57 (of 60) children age 5 to 15 years presenting to emergency departments with asthma in 2 communities in Canada between September 10 and 30, 2001, (cases) were compared with those in 157 age-matched volunteer children with asthma of comparable severity studied simultaneously (controls).Results: Human picornaviruses were detected in 52% of cases and 29% of controls (P=.002) and viruses of any type in 62% of cases and 41% of controls (P =.011). Cases were less likely to have been prescribed controller medication (inhaled corticosteroid, 49% vs 85%; P