Development of a probucol-releasing antithrombogenic drug eluting stent.
Development of a probucol-releasing antithrombogenic drug eluting stent.
复制标题
开发释放普罗布考的抗血栓药物洗脱支架。
DOI：
10.1002/jbm.b.32672
复制
发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Park,Kinam
中科院分区：
文献类型：
--
作者：
Vedantham,Kumar;Chaterji,Somali;Kim,SungWon;Park,Kinam
The success of drug eluting stents (DESs) has been challenged by the manifestation of late stent thrombosis after DES implantation. The incomplete regeneration of the endothelial layer poststenting triggers adverse signaling processes precipitating in thrombosis. Various approaches have been attempted to prevent thrombosis, including the delivery of biological agents, such as estradiol, that promote endothelialization, and the use of natural polymers as coating materials. The underlying challenge has been the inability to release the biological agent in synchronization with the temporal sequence of vascular wound healingin vivo. The natural healing process of the endothelium after an injury starts after a week and may take up to a month in humans. This article presents a novel DES formulation using a hemocompatible polyurethane (PU) matrix to sustain the release of probucol (PB), an endothelial agonist, by exploiting the greater difference in the solubility parameters of PB and PU. This results in the formation of crystalline PB aggregates retarding drug release from PU. The physicochemical properties of PB in PU were confirmed using differential scanning calorimetry and X‐ray diffraction. Drug‐polymer compatibility was examined using infrared spectral analysis. Also,in vitrostudies using primary human aortic endothelial cells resulted in the selection of 5% w/w PB as the optimal dose, to be further testedin vitroandin vivo. This work develops and tests a promising new DES formulation to enable faster endothelial cell proliferation poststenting, potentially minimizing the incidence and severity of thrombotic events after DES implantation. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.
登录
查看更多内容
物理化学因素对聚（L-乳酸）（L-PLA）微丸中亲水性药物释放动力学的影响。
影响因子：
3.4
作者：
A. Kader;R. Jalil
通讯作者：
R. Jalil
评估溶解度参数以预测无定形和结晶头孢托仑匹酯的表观溶解度
DOI：
10.1016/s0031-6865(99)00018-7
发表时间：
1999
期刊：
Pharmaceutica Acta Helvetiae
影响因子：
--
作者：
M. Ohta;T. Oguchi;Keiji. Yamamoto
通讯作者：
Keiji. Yamamoto
影响因子：
6.5
作者：
SLOAN, KB;KOCH, SAM;FLOWERS, FP
通讯作者：
FLOWERS, FP
影响因子：
14
作者：
Lee, Yong-Kyu;Park, Jae Hyung;Byun, Youngro
通讯作者：
Byun, Youngro
excel支架：很好的DES，但6个月后我们真的能停止氯吡格雷吗？
DOI：
10.1016/j.jcin.2009.01.005
发表时间：
2009
期刊：
JACC. Cardiovascular interventions
影响因子：
--
作者：
J. Margolis
通讯作者：
J. Margolis