Characteristics of general distribution of hepatitis B virus genotypes in China.
Characteristics of general distribution of hepatitis B virus genotypes in China.
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发表时间：
2009-08
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通讯作者：
Chang-Tai Zhu;Chunlei Dong
中科院分区：
文献类型：
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作者：
Chang-Tai Zhu;Chunlei Dong
基于病毒核苷酸序列的差异，目前将B型肝炎病毒（HBV）基因型分为基因型A-H。HBV基因型的地理分布在不同国家和地区不同。为了解中国大陆HBV基因型分布的一般特征，我们对国内发表的HBV基因型研究文献进行了综述。方法检索万方数据库和中国知网数据库中有关乙型肝炎病毒的文章，按基因型和纬度分类，用SPSS11.0软件进行统计分析。结果HBV基因型以C、B、BC为主，分别占50.99%、35.58%、6.07%，其他基因型少见。纬度与基因型B率呈负相关（r=-0.782，P0.05）。结论我国HBV基因型以C型为主，其次为C型和混合型BC，A、D及其他基因型少见。随着纬度的增加，基因型B的分布逐渐减少，而基因型C的分布有增加的趋势。其他基因型没有表现出任何变化。
BACKGROUND Based on differences in the virus nucleotide sequence, hepatitis B virus (HBV) genotypes are presently divided into genotypes A-H. The geographic distributions of HBV genotypes differ in countries and regions. To determine the general characteristics of their distributions in the mainland of China, we reviewed articles on HBV genotypes published in China. METHODS The Wanfang Database and the CNKI Database were searched for original articles involving HBV in China, and then the data from the articles were classified according to genotype and latitude and analyzed using SPSS 11.0. RESULTS The main HBV genotypes were C, B and BC, and their rates were 50.99%, 35.58%, 6.07%, respectively; other genotypes were rare. There was a negative correlation between latitude and the rate of genotype B (r=-0.782, P0.05). CONCLUSIONS In China, HBV genotype C predominates, followed by genotype C and mixed genotype BC; genotypes A, D and others are rare. With an increasing latitude, the distribution of genotype B decreases gradually, while that of genotype C tends to increase. The other genotypes do not show any changes.