Oral tolerance in a murine model of relapsing experimental autoimmune uveoretinitis (EAU): Induction of protective tolerance in primed animals
Oral tolerance in a murine model of relapsing experimental autoimmune uveoretinitis (EAU): Induction of protective tolerance in primed animals
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DOI：
10.1046/j.1365-2249.1997.4571356.x
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发表时间：
1997-08-01
影响因子：
4.6
通讯作者：
Caspi, RR
中科院分区：
文献类型：
--
作者：
Thurau, SR;Chan, CC;Caspi, RR
口服致葡萄膜视网膜抗原抑制EAU的表达诱导随后的免疫与这些抗原。EAU口服耐受的有效性和机制主要是在刘易斯大鼠的急性、单相模型中通过在疾病诱导之前喂食抗原来研究的。在本研究中，我们研究了口服耐受诱导在B10.A小鼠急性和慢性复发模型中的作用。在急性小鼠EAU中，我们可以通过在免疫前诱导口服耐受来有效地抑制疾病。在慢性复发性EAU中，只有在动物从第一次葡萄膜炎发作中恢复后才开始抗原喂养。在这些实验条件下，随后的复发在很大程度上得到了预防。这些实验表明口服耐受性可能在葡萄膜炎中具有实际的临床意义，葡萄膜炎在人类中主要是一种慢性复发性疾病。
Oral administration of uveitogenic retinal antigens suppresses the expression of EAU induced by a subsequent immunization with these antigens. Effectiveness and mechanisms of oral tolerance in EAU have mainly been studied in the acute, monophasic model in Lewis rats by feeding antigen prior to induction of disease. In this study we investigated the effect of oral tolerance induction in the acute as well as the chronic-relapsing models in the B10.A mouse. In acute murine EAU we could effectively suppress disease by induction of oral tolerance prior to immunization. In the chronic-relapsing EAU, antigen feeding was started only after the animals had recovered from their first attack of uveitis. Under these experimental conditions the subsequent relapse was largely prevented. These experiments demonstrate that oral tolerance may have practical clinical implications in uveitis, which is predominantly a chronic-relapsing condition in humans.