STUDIES ON ANTINEPHRITIC EFFECTS OF PLANT-COMPONENTS (3) - EFFECT OF PACHYMAN, A MAIN COMPONENT OF PORIA-COCOS WOLF ON ORIGINAL-TYPE ANTI-GBM NEPHRITIS IN RATS AND ITS MECHANISMS
STUDIES ON ANTINEPHRITIC EFFECTS OF PLANT-COMPONENTS (3) - EFFECT OF PACHYMAN, A MAIN COMPONENT OF PORIA-COCOS WOLF ON ORIGINAL-TYPE ANTI-GBM NEPHRITIS IN RATS AND ITS MECHANISMS
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DOI：
10.1254/jjp.59.89
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发表时间：
1992-05-01
期刊：
影响因子：
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通讯作者：
SUZUKI, Y
中科院分区：
文献类型：
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作者：
HATTORI, T;HAYASHI, K;SUZUKI, Y
研究了茯苓多糖对大鼠原型抗GBM肾炎的抗肾炎作用。从注射抗GBM血清之日起，将Pachyman给予原始型抗GBM肾病大鼠10天。 Pachyman 可防止尿蛋白排泄和血清胆固醇含量升高。肾小球的组织病理学观察表明，尽管肾病对照组大鼠鲍曼氏囊的细胞核数量和毛细血管壁粘附显着增加，但与对照组相比，茯苓粉降低了组织病理学变化的程度，例如细胞增多和粘附。虽然对照组血清补体CH50比例明显低于正常组，但茯苓多糖可抑制血清补体CH50的下降，且茯苓多糖治疗组大鼠肾小球C3沉积明显减少。这些结果表明，茯苓多糖对大鼠原始型抗GBM肾炎有效，并且茯苓多糖的抗肾炎机制可能部分归因于该药物对肾小球中C3沉积的抑制作用。
The antinephritic effect of pachyman on original-type anti-GBM nephritis in rats was investigated. Pachyman was given to original-type anti-GBM nephritic rats for 10 days from the day of anti-GBM serum injection. Pachyman prevented urinary protein excretion and the elevation of serum cholesterol content. Histopathological observations of the glomeruli indicated that although the number of nuclei and adhesion to capillary walls of Bowman's capsule in nephritic control rats were significantly increased, pachyman reduced the degree of histopathological changes such as hypercellularity and adhesion as compared to the control group. Although the serum complement CH50 ratio in control group was significantly lower than that in the normal group, the decrease in serum complement CH50 was inhibited by pachyman, and rat C3 deposition in the glomeruli in the pachyman-treated group was significantly reduced. These results suggest that pachyman was effective against original-type anti-GBM nephritis in rats and that the antinephritic mechanisms of pachyman may be partly due to the inhibitory action of this agent on C3 deposition in the glomeruli.