Prohibitin mutations are uncommon in prostate cancer families linked to chromosome 17q.
Prohibitin mutations are uncommon in prostate cancer families linked to chromosome 17q.
复制标题
抑制素突变在与 17q 染色体相关的前列腺癌家族中并不常见。
DOI：
10.1038/sj.pcan.4500878
复制
发表时间：
2006
影响因子：
4.8
通讯作者：
Cooney,KA
中科院分区：
文献类型：
--
作者：
White,KA;Lange,EM;Ray,AM;Wojno,KJ;Cooney,KA
背景：连锁研究为前列腺癌易感基因位于染色体17 q提供了证据。方法：对32名参与密歇根大学前列腺癌遗传学项目的男性进行了基因组测序，分析了该基因的所有编码区和内含子/外显子连接，并证明该基因与17 q标记连锁。尽管鉴定了许多核苷酸变异，但在来自32个无关的多发性前列腺癌家族的32名前列腺癌男性中没有鉴定出编码区替换。在PCGP家族中检测到的17 q21 -22上的连锁信号似乎与PHB突变无关。该区域的精细定位正在进行中，以完善候选区域并突出显示用于序列分析的其他候选前列腺癌易感基因。
Background: Linkage studies have provided evidence for a prostate cancer susceptibility locus on chromosome 17q. The mitochondrial protein prohibitin (PHB) is a plausible candidate gene based on its chromosomal location (17q21) and known function.Methods: All coding regions and intron/exon junctions of the PHB gene were sequenced in 32 men from families participating in the University of Michigan Prostate Cancer Genetics Project that demonstrated evidence of linkage to 17q markers.Results: Although a number of nucleotide variants were identified, no coding region substitutions were identified in any of the 32 men with prostate cancer from 32 unrelated multiplex prostate cancer families.Conclusions: PHB mutations do not appear to account for the linkage signal on 17q21–22 detected in PCGP families. Fine mapping of this region is in progress to refine the candidate region and highlight additional candidate prostate cancer susceptibility genes for sequence analysis.