Declining childhood and adolescent cancer mortality.
Declining childhood and adolescent cancer mortality.
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DOI：
10.1002/cncr.28748
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发表时间：
2014-08-15
期刊：
影响因子：
6.2
通讯作者：
Seibel, Nita L.
中科院分区：
文献类型：
--
作者：
Smith, Malcolm A.;Altekruse, Sean F.;Adamson, Peter C.;Reaman, Gregory H.;Seibel, Nita L.
为了评估在为患有癌症的儿童和青少年寻找更有效的治疗方法方面是否继续取得进展，我们检查了美国总体和特定疾病的儿童癌症死亡率，重点是2000-2010年的数据。使用连接点回归分析估计了1975至2010年间年龄调整后的美国死亡率趋势。对于20岁、15岁和15-19岁的年龄组，对相同的诊断分组进行了年度百分比变化(APC)分析，时间限制为2000-2010年。儿童癌症死亡率在1998年至2002年达到平稳(平均预测数=0.3)后，2002年至2010年儿童癌症死亡率的年降幅(−2.4%)与1975年至1998年(−2.7%)的降幅相似。2000年至2010年，急性淋巴细胞性白血病、急性髓系白血病、非霍奇金淋巴瘤、霍奇金淋巴瘤、神经母细胞瘤、中枢神经系统癌和性腺癌的死亡率显著下降。2000-2010年，15-19岁组的死亡率下降速度一般等于或大于0-14岁组。自1975年以来的治疗改进导致超过4.5万人在2010年避免了癌症死亡。儿童和青少年的癌症死亡率从2000年到2010年都有所下降，多种癌症类型的死亡率也出现了显著下降。然而，美国每年仍有1900多名儿童和青少年死于癌症，许多幸存者受到长期影响，限制了他们的生活质量。继续进行研究，以确定产生较少长期后遗症的更有效的治疗方法，对于解决这些剩余的挑战至关重要。
To evaluate whether progress continues in identifying more effective treatments for children and adolescents with cancer, we examined overall as well as disease-specific childhood cancer mortality rates for the United States, focusing on data for 2000–2010. Age-adjusted United States mortality trends for 1975 to 2010 were estimated using joinpoint regression analysis. Analyses of annual percentage change (APC) were performed on the same diagnostic groupings for the time period restricted to 2000–2010 for < 20, < 15 and 15–19 year age groupings. Following a plateau in mortality rates from 1998–2002 (APC = 0.3), the annual decline in childhood cancer mortality for 2002–2010 (−2.4%) was similar to that observed from 1975 to 1998 (−2.7%). Statistically significant declines in mortality rates for 2000–2010 were noted for acute lymphoblastic leukemia, acute myeloid leukemia, non-Hodgkin lymphoma, Hodgkin lymphoma, neuroblastoma, CNS cancers, and gonadal cancers. For 2000–2010, the rates of decline in mortality for the 15–19 year group were generally equal to or greater than those of the 0–14 year group. Improvements in treatment since 1975 resulted in over 45,000 cancer deaths averted through 2010. Cancer mortality for both children and adolescents declined from 2000–2010, with significant declines observed for multiple cancer types. However, over 1900 cancer deaths still occur each year among children and adolescents in the United States, and many survivors experience long-term effects that limit their quality of life. Continued research directed towards identifying more effective treatments that produce fewer long-term sequelae is critical to address these remaining challenges.
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影响因子：
45.3
作者：
Schultz, Kirk R.;Bowman, W. Paul;Camitta, Bruce
通讯作者：
Camitta, Bruce
影响因子：
17.1
作者：
Connor, Edward;Cure, Pablo
通讯作者：
Cure, Pablo
DOI：
10.1126/science.1164382
发表时间：
2008-09-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Parsons DW;Jones S;Zhang X;Lin JC;Leary RJ;Angenendt P;Mankoo P;Carter H;Siu IM;Gallia GL;Olivi A;McLendon R;Rasheed BA;Keir S;Nikolskaya T;Nikolsky Y;Busam DA;Tekleab H;Diaz LA Jr;Hartigan J;Smith DR;Strausberg RL;Marie SK;Shinjo SM;Yan H;Riggins GJ;Bigner DD;Karchin R;Papadopoulos N;Parmigiani G;Vogelstein B;Velculescu VE;Kinzler KW
通讯作者：
Kinzler KW
影响因子：
45.3
作者：
Pro, Barbara;Advani, Ranjana;Shustov, Andrei
通讯作者：
Shustov, Andrei
影响因子：
4.7
作者：
Orentas RJ;Lee DW;Mackall C
通讯作者：
Mackall C