THE ROLE OF PROTEOLYTIC ENZYMES IN THE PRODUCTION OF PRURITUS IN MAN
THE ROLE OF PROTEOLYTIC ENZYMES IN THE PRODUCTION OF PRURITUS IN MAN
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DOI：
10.1038/jid.1955.138
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发表时间：
1955-01-01
影响因子：
6.5
通讯作者：
SHELLEY, WB
中科院分区：
文献类型：
--
作者：
ARTHUR, RP;SHELLEY, WB
植物和动物来源的内肽酶被发现是一种独特有效的化学刺激物，可引起人类瘙痒症，通过骨针技术将其引入表皮，在没有任何可见皮肤变化的情况下引起严重的持续性皮炎。据推测，表皮中蛋白酶的激活释放在瘙痒中起重要作用。
Endopeptidases of both plant and animal sources were found to be a uniquely effective chemical stimulus for the production of pruritus in man. Introduced into the epidermis by a spicule technique they elicit a severe sustained pruritis in the absence of any visible cutaneous change. It is postulated that the release of activation of proteinases in the epidermis plays a significant role in itching.