The ratio of plasma to whole-blood serotonin may be a novel marker of atherosclerotic cardiovascular disease
The ratio of plasma to whole-blood serotonin may be a novel marker of atherosclerotic cardiovascular disease
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DOI：
10.1016/j.lab.2004.03.014
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发表时间：
2004-07-01
期刊：
影响因子：
--
通讯作者：
Takahashi, H
中科院分区：
文献类型：
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作者：
Hara, K;Hirowatari, Y;Takahashi, H
由于动脉粥样硬化性血管病变刺激血小板，血小板释放血清素（5-羟色胺，又名5-HT）。因此，我们不仅在血小板缺乏的血浆中，而且在全血中测量5-羟色胺浓度，作为评估血管病变的一种手段。血浆5-羟色胺浓度随年龄的增长呈上升趋势，而全血5-羟色胺浓度则呈下降趋势。因此血浆5-羟色胺与全血浓度之比（P/WB）随年龄增加而增加。这可能是动脉粥样硬化性血管损伤的老年受试者血小板活化的结果。经冠状动脉造影（CAG）的患者根据诊断分为4组：努力诱发性心绞痛（eAP）、陈旧性心肌梗死（OMI）、血管痉挛性心绞痛（VSAP）、不稳定型心绞痛（uAP）。eAP、uAP、ON和VSAP患者的平均血浆5-HT浓度显著高于健康对照组（P < 0.01），而eAP患者的全血浓度低于健康对照组（P < 0.01）。当计算P/WB比值时，所有疾病组的平均水平均显著高于健康对照组。这些发现表明，5-羟色胺从血小板释放到血浆中，并且在动脉粥样硬化患者血小板中的浓度降低。
Because atherosclerotic vascular lesions stimulate platelets, the platelets release serotonin (5-hydroxytryptamine, aka 5-HT). We therefore measured 5-HT concentrations not only in platelet-poor plasma but also in whole blood as a means of assessing vascular lesions. The plasma concentration of 5-HT tended to increase with age, whereas that in whole blood decreases. Therefore the ratio of the plasma to the whole-blood concentration of 5-HT (P/WB) increases with age. This may be a result of the activation of platelets in older subjects with atherosclerotic vascular damage. Patients who underwent coronary angiography (CAG) were classified into 4 groups according to diagnosis: effort-induced angina pectoris (eAP), old myocardial infarction (OMI), vasospastic angina pectoris (VSAP), and unstable angina (uAP). The mean plasma 5-HT concentration was significantly (P < .01) greater in patients with eAP, uAP, ON, and VSAP than in healthy controls, whereas the concentration in whole blood was lower in patients with eAP than in healthy controls. When the P/WB ratios were calculated, the mean levels in all disease groups were significantly higher than that in the healthy controls. These findings suggested that 5-HT is released into the plasma from the platelets and that the concentration in the platelets decreases in patients with atherosclerosis.