Novel Trivalent C3-Symmetrical Phenylboronic Acid Pinacol Esters
Novel Trivalent C3-Symmetrical Phenylboronic Acid Pinacol Esters
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新型三价 C3-对称苯基硼酸频哪醇酯
DOI：
10.1080/00304948.2017.1320929
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发表时间：
2017
影响因子：
1.5
通讯作者：
K. Sumoto
中科院分区：
文献类型：
--
作者：
Makoto Furutachi;S. Fuchigami;Toshiaki Gondo;Saho Goto;K. Ako;K. Sumoto
由于对称性多价分子具有良好的临床或药理价值，在寻找生物活性化合物方面受到了极大的关注。为此，最近报道了许多合成的具有生物活性的C2对称二价分子，用于开发新的药物来治疗由受体功能障碍引起的感染性疾病。与相应的单价分子相比，多价分子通常显示出更强的生物学潜力。关于识别糖类的分子，最近人们在碳水化合物的合成受体和检测器的设计上做了大量的工作。从这个角度来看，我们对硼酸及其相关同系物特别感兴趣，因为许多硼酸衍生物(A)与1，2-二醇官能团反应生成具有可逆共价键的环状衍生物(B)(见方案1)。我们一直对干扰碳水化合物识别阶段的分子感兴趣，以便找到新的生物活性线索。
Much attention has been given to symmetrical multivalent molecules in the search for bioactive compounds due to their promising clinical or pharmacological value. For this reason, many synthetic bioactive C2-symmetrical bivalent molecules have recently been reported for the development of new agents to treat infectious diseases caused by dysfunction of receptors. A multivalent molecule is generally expected to show enhanced biological potential compared to that of the corresponding monovalent molecule. Regarding molecules for the recognition of saccharides, considerable work has recently been done on the design of synthetic receptors and detectors for carbohydrates. From this point of view, we have been particularly interested in boronic acids and related congeners because many boronic acid derivatives (A) react with 1,2-diol functionalities to generate cyclic derivatives (B) with reversible covalent bonds (see Scheme 1). We have been interested in molecules that interfere with such carbohydrate recognition stages in order to find new bioactive leads.
对称苯基硼酸衍生物的制备及其生物活性
DOI：
--
发表时间：
2018
期刊：
影响因子：
--
作者：
Furutachi M.;Yokomizo K.;Zhou J.-R.;Kashige N.;Miake F.;Sumoto K.
通讯作者：
Sumoto K.