Prolactin May Be Increased in Newly Diagnosed Celiac Children and Adolescents and Decreases after 6 Months of Gluten-Free Diet
Prolactin May Be Increased in Newly Diagnosed Celiac Children and Adolescents and Decreases after 6 Months of Gluten-Free Diet
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DOI：
10.1159/000357064
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发表时间：
2014-01-01
影响因子：
3.2
通讯作者：
Cavallo, Luciano
中科院分区：
文献类型：
--
作者：
Delvecchio, Maurizio;Faienza, Maria Felicia;Cavallo, Luciano
背景/目的：催乳素(PRL)由脑下垂体分泌。它不仅在乳腺上发挥作用，而且在自身免疫机制中也起到调节作用。乳糜泻(CD)是一种面筋敏感型自身免疫性肠病，有时与自身免疫性内分泌疾病有关。CD患者的PRL水平在诊断时没有数据，也没有确凿的数据报道。方法：我们的目的是评估新诊断的CD儿童患者的PRL分泌，以及在高催乳素血症的情况下，患者在无麦谷饮食(GFD)期间其水平的变化。我们招募了67名患者和39名健康对照。结果：CD组PRL(13.5+/-9.2 ng/ml)显著高于对照组(8.5+/-5.0 ng/ml)。CD组PRL与发病年龄呈负相关(r=-0.326；p=0.007)。在确诊为高催乳素血症的患者中，GFD治疗6个月后PRL下降。结论：本研究证实了CD诊断时PRL可能升高，并首次证实GFD短病程后PRL降低。CD中炎性细胞因子水平的变化可能是PRL水平变化的原因。年轻的患者似乎比年长的患者更容易患上高催乳素血症。(C)2014年S.Karger AG，巴塞尔
Background/Aims: Prolactin (PRL) is produced by the anterior pituitary gland. It exerts its role on the breast gland but also plays a modulatory role in autoimmune mechanisms. Celiac disease (CD) is a gluten-sensitive autoimmune enteropathy sometimes associated with autoimmune endocrinopathies. No data on PRL levels in CD patients are available at diagnosis, and no conclusive data are reported. Methods: We aimed to evaluate PRL secretion in newly diagnosed CD pediatric patients and, in the case of hyperprolactinemia, any changes in its levels while the patients were on a glutenfree diet (GFD). We recruited 67 patients and 39 healthy controls. Results: PRL was statistically higher in the CD patients (13.5 +/- 9.2 ng/ml) than in the controls (8.5 +/- 5.0 ng/ml). In the CD group, PRL was inversely correlated with the age at diagnosis (r = -0.326; p = 0.007). In patients with hyperprolactinemia at diagnosis, PRL decreased after 6 months of GFD. Conclusion: This paper confirms that PRL may be increased at diagnosis of CD and shows, for the first time, that it de-creases after a short course of GFD. Changes in the levels of inflammatory cytokines in CD may account for changes in PRL levels. Younger patients seem more prone to develop hyperprolactinemia than older ones. (C) 2014 S. Karger AG, Basel