Characterization of Inflammatory Breast Cancer in Hispanic Women from Puerto Rico.
Characterization of Inflammatory Breast Cancer in Hispanic Women from Puerto Rico.
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DOI：
10.7150/jca.77108
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发表时间：
2022
影响因子：
3.9
通讯作者：
Martínez-Montemayor MM
中科院分区：
文献类型：
--
作者：
Quirindongo-Rivera C;Rullán-Varela V;Underill Z;Rivera M;Ortiz-Ortiz KJ;Martínez-Montemayor MM
Background: Breast cancer (BC) is the most diagnosed cancer and the leading cause of cancer death among women in Puerto Rico (PR). Inflammatory breast cancer (IBC) is considered the most aggressive BC subtype. This study characterized the IBC population of Hispanic women living in Puerto Rico and aimed to estimate the IBC survival rate using data from the Puerto Rico Central Cancer Registry (PRCCR). Methods: This is a retrospective, population-based study using the PRCCR database and the Health Insurance Linkage Database (PRCCR-HILD). We analyzed data from patients that were diagnosed with IBC from January 1, 2008 to December 31, 2018. Patients were identified using the International Classification of Diseases for Oncology, 3rd edition (ICD-O-3) site codes C50.0-C50.9 and histology code 8530. Variables such as age at diagnosis, marital status, health insurance, geographic area of residence, staging variables, tumor receptor subtypes, treatment received, and overall survival (OS) were studied. Statistical analysis methods were employed to describe the population, estimate survival curves and examine the risk of dying. Results: The data of 51 patients were included. The mean age at diagnosis of IBC in the current study was 59 years old. A total of 62.8% of patients had no metastases at diagnosis and 64.7% were diagnosed with stage III disease. Most tumors presented with ER+/PR+/Her2- (21.6%), or a triple negative (ER-/PR-/Her2-, 15.7%) tumor concordance. The OS during the first year was 66% (90% CI: 0.54-0.76), whereas 36 months post-diagnosis was at a low 39% (90% CI: 0.27-0.59). The triple-negative subtype had the worst survival at 36 months (36% [90% CI: 0.11-0.62]). This study revealed through Cox regression analysis that women with stage IV disease and those with ER-/PR- tumor subtype have a higher risk of dying (HR 4.99; [90% CI: 2.30-10.83] and HR 4.74; [90% CI: 1.88-11.95]), respectively. Conclusions: Our results suggest that the Puerto Rican IBC patient population presents unique characteristics. This is the first research to describe the patient profile and characteristics of women diagnosed with IBC in PR. This research increases awareness about this lethal disease in PR.
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影响因子：
7.3
作者：
Dano D;Lardy-Cleaud A;Monneur A;Quenel-Tueux N;Levy C;Mouret-Reynier MA;Coudert B;Mailliez A;Ferrero JM;Guiu S;Campone M;de La Motte Rouge T;Petit T;Pistilli B;Dalenc F;Simon G;Lerebours F;Chabaud S;Bertucci F;Gonçalves A
通讯作者：
Gonçalves A
影响因子：
2.1
作者：
Hirko, Kelly A.;Soliman, Amr S.;Schwartz, Kendra
通讯作者：
Schwartz, Kendra
影响因子：
13.8
作者：
Cone EB;Marchese M;Paciotti M;Nguyen DD;Nabi J;Cole AP;Molina G;Molina RL;Minami CA;Mucci LA;Kibel AS;Trinh QD
通讯作者：
Trinh QD
影响因子：
3.7
作者：
Curcio, LD;Rupp, E;Wagman, LD
通讯作者：
Wagman, LD
DOI：
10.1016/s1470-2045(17)30192-4
发表时间：
2017-04
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Fouad TM;Barrera AMG;Reuben JM;Lucci A;Woodward WA;Stauder MC;Lim B;DeSnyder SM;Arun B;Gildy B;Valero V;Hortobagyi GN;Ueno NT
通讯作者：
Ueno NT