The Genomics Education Partnership
The Genomics Education Partnership
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基因组学教育合作伙伴
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
D. Lopatto
中科院分区：
文献类型：
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作者：
Charles Hauser;Cheryl Bailey;S. C. Elgin;D. Lopatto
基因组测序技术的进步产生了大量的公开数据，为学生与科学家的研究伙伴关系创造了新的机会。通过适当的培训，本科生可以提供有效使用序列数据所需的劳动密集型序列改进和注释。基因组学教育合作伙伴 (GEP) 将来自 40 多所学院和大学的教师聚集在一起开展一个合作项目，为学生提供基因组学的研究经验。 GEP 开展的第一个项目是对几种果蝇物种的点染色体进行序列改进和注释。这个独特的结构域具有常染色质（包括正常基因密度）和异染色质的特性。本科生将发布的序列数据改进至错误率低于1:1000 bp，并生成经过仔细注释的基因模型；汇集的数据用于对整个染色体进行分析，包括不同果蝇物种之间的比较。学生们很高兴有机会为科学数据库做出新颖的贡献，并且他们的工作将产生科学出版物。我们发现基因组学研究对我们来说是一种有益的教学方式，对我们的学生来说也是一种有益的学习方式。我们正在寻找更多的学校加入我们，以及来自科学界的更多合作伙伴，为学生提出有意义的注释问题来解决。由 HHMI 和 NIH 的赠款资助。
The advances in genome sequencing technology have led to the generation of massive amounts of publicly available data creating new opportunities for student‐scientist research partnerships. With appropriate training, undergraduate students can provide the labor‐intensive sequence improvement and annotation required for effective use of sequence data. The Genomics Education Partnership (GEP) brings together faculty from over 40 colleges and universities in a collaborative project to provide their students with a research experience in genomics. The first project undertaken by the GEP is the sequence improvement and annotation of the dot chromosomes of several Drosophila species. This unique domain has properties of both euchromatin, including normal gene density, and heterochromatin. Undergraduates improved the posted sequence data to an error rate of less than 1:1000 bp, and generate carefully annotated gene models; the pooled data is being used for analysis of the chromosome as a whole, including comparisons among different Drosophila species. Students appreciate the opportunity to make novel contributions to the scientific database, and that their work will result in a scientific publication. We find that genomics research is a rewarding way for us to teach, and a rewarding way for our students to learn. We are looking for additional schools to join us, and additional partners from the scientific community to pose meaningful annotation problems for the students to tackle. Funded by grants from HHMI and NIH.