Highly Enantioselective Cobalt-Catalyzed Hydrosilylation of Alkenes
Highly Enantioselective Cobalt-Catalyzed Hydrosilylation of Alkenes
复制标题
高对映选择性钴催化烯烃氢化硅烷化
DOI：
10.1021/jacs.7b04137
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发表时间：
2017-07-19
影响因子：
15
通讯作者：
Lu, Zhan
中科院分区：
文献类型：
--
作者：
Cheng, Biao;Lu, Peng;Lu, Zhan
为高效合成有价手性二氢硅烷，研究了一种钴催化的高马尔可夫尼科夫型对映选择性烯烃硅氢化反应。该协议操作简单且原子经济，并且使用相对简单且容易获得的起始材料。该反应既适用于芳基烯烃，也适用于脂肪烯烃，具有良好的官能团耐受性。这个反应很容易在克的尺度上进行。TOF和TON分别高达1800和860。
A cobalt-catalyzed highly Markovnikov-type and enantioselective hydrosilylation of alkenes is developed for the efficient synthesis of valuable chiral dihydrosilanes. This protocol is operationally simple and atom-economy, and using relatively simple and readily available starting materials. The reaction is suitable for both aryl and aliphatic alkenes with excellent functional group tolerability. The reaction could be easily carried out in a gram-scale. The TOF and TON is up to 1800 and 860, respectively.