THE EFFECTS OF HIGH DIETARY ZINC AND COPPER DEFICIENCY ON THE ACTIVITY OF COPPER-REQUIRING METALLOENZYMES IN THE GROWING-RAT
THE EFFECTS OF HIGH DIETARY ZINC AND COPPER DEFICIENCY ON THE ACTIVITY OF COPPER-REQUIRING METALLOENZYMES IN THE GROWING-RAT
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DOI：
10.1093/jn/114.5.813
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发表时间：
1984-01-01
影响因子：
4.2
通讯作者：
FISCHER, PWF
中科院分区：
文献类型：
--
作者：
LABBE, MR;FISCHER, PWF
The effects of feeding rats high levels of dietary Zn (240 mg Zn/kg diet) on the activities of the Cu-requiring metalloenzymes: ceruloplasmin (Cp), cupro-zinc superoxide dismutase (SOD) and cytochrome c oxidase (CCO) were determined. These were compared with those seen during Cu deficiency (induced by feeding 0.6 mg Cu/kg diet). The activities of Cp in serum, Cu-Zn SOD in liver and heart and CCO in heart were significantly reduced in both the high Zn and Cu-deficient groups by 2 wk, when compared to the activities seen in rats fed the control diet (6 mg Cu, 30 mg Zn/kg diet). In animals fed the high Zn diet, the reduction in heart CCO activity followed the decrease seen in heart Cu concentration, whereas in blood and liver, the reductions in Cp and SOD activities, respectively, were greater than the reductions seen in Cu concentration. The results of this experiment demonstrate that with high dietary Zn, the reductions seen in the activity of Cu-requiring metalloenzymes were similar to those seen during Cu deficiency.
