N-Alkanes in normal and pathological human scale.
N-Alkanes in normal and pathological human scale.
复制标题
正常和病理人体范围内的正烷烃。
DOI：
10.1016/0006-291x(82)91707-7
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发表时间：
1982
影响因子：
3.1
通讯作者：
Elias,PM
中科院分区：
文献类型：
--
作者：
Williams,ML;Elias,PM
当在哺乳动物组织中发现正构烷烃时，它们被认为仅仅是外源性的，并且没有被赋予任何正常或病理功能。我们在正常角质层（总脂质5.5±0.2%）中定期观察到正构烷烃，并在一些鳞屑疾病中发现惊人的积累（> 25%总脂质）。尽管这些正构烷烃的来源尚不清楚，但有证据表明它们并非由外部污染物、药物、皮脂腺以及自发或细菌降解产生。人体角质层中存在大量正构烷烃，表明它们可能在人体正常表皮功能和某些表皮疾病的病理生理学中发挥作用。
When n-alkanes have been found in mammalian tissues, they have been considered to be solely of exogenous origin, and have not been assigned any normal or pathological function. We have observed n-alkanes regularly in normal stratum corneum (5.5±0.2% total lipid), and found striking accumulations (> 25% total lipid) in some scaling diseases. Although the origin of these n-alkanes is not known, evidence is presented that they do not arise from external contaminants, medications, sebaceous glands, and spontaneous or bacterial degradation. The presence of large quantities of n-alkanes in human stratum corneum suggests that they may play a role in normal human epidermal function and in the pathophysiology of some epidermal diseases.