Shaping the CD4+ memory immune response against tuberculosis: the role of antigen persistence, location and multi-functionality.
Shaping the CD4+ memory immune response against tuberculosis: the role of antigen persistence, location and multi-functionality.
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DOI：
10.1515/bmc.2011.051
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发表时间：
2012-02-01
影响因子：
--
通讯作者：
Kirman, Joanna
中科院分区：
文献类型：
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作者：
Ancelet, Lindsay;Kirman, Joanna
摘要针对细胞内病原体（如结核病（TB））的有效疫苗接种依赖于CD4记忆T细胞的产生和维持。对记忆免疫反应的不完全理解阻碍了新的、更有效的结核病疫苗的合理设计。本文综述了抗原的持久性，记忆细胞的位置，以及它们的多功能能力如何塑造CD4记忆T细胞对结核病的反应。
Abstract Effective vaccination against intracellular pathogens, such as tuberculosis (TB), relies on the generation and maintenance of CD4 memory T cells. An incomplete understanding of the memory immune response has hindered the rational design of a new, more effective TB vaccine. This review discusses how the persistence of antigen, the location of memory cells, and their multifunctional ability shape the CD4 memory T cell response against TB.