COMPARATIVE-STUDY OF THE INTRAOCULAR-PRESSURE EFFECTS OF FLUOROMETHOLONE 0.1-PERCENT VERSUS DEXAMETHASONE 0.1-PERCENT
COMPARATIVE-STUDY OF THE INTRAOCULAR-PRESSURE EFFECTS OF FLUOROMETHOLONE 0.1-PERCENT VERSUS DEXAMETHASONE 0.1-PERCENT
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DOI：
10.1136/bjo.67.10.661
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发表时间：
1983-01-01
影响因子：
4.1
通讯作者：
AKINGBEHIN, AO
中科院分区：
文献类型：
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作者：
AKINGBEHIN, AO
对24对配对眼进行皮质类固醇激发试验，比较0.1%氟米松和0.1%地塞米松的眼压效应。在地塞米松治疗的24只眼中，15只眼(62.5%)的眼压变化大于5毫米汞柱，平均差值为8.58毫米汞柱，范围为0至+20毫米汞。在24只接受氟甲醇酮治疗的眼睛中，只有2只眼(8.3%)的眼压发生了变化，平均差值为2.96 mm Hg，范围为-2至+14 mm Hg。外用地塞米松和氟米松对眼压的影响有非常显著的统计学差异(相关t检验，P<；0.001)。氟米松似乎是青光眼患者和其他已知类固醇患者的首选局部类固醇，如果需要局部类固醇治疗的话。
The intraocular pressure effect of fluorometholone 0.1% was compared with that of dexamethasone 0.1% by performing corticosteroid provocative tests on 24 matched pairs of eyes. Of the 24 dexamethasone treated eyes, 15 (62.5%), showed a change in intraocular pressure greater than 5 mmHg, with mean .DELTA.P = 8.58 mmHg and range 0 to +20 mmHg. Only 2 of the 24 fluorometholone treated eyes, 8.3%, showed a change in pressure > 5 mmHg, with mean .DELTA.P = 2.96 mm Hg and range -2 to +14 mm Hg. There was a highly statistically significant difference between the intraocular pressure effects of topical dexamethasone and fluorometholone (corrlated t test, P < 0.001). Fluorometholone seems to be the the topical steroid of choice for patients with glaucoma and other known steroid when topical steroid treatment is indicated.