Effects of carnitine and some related compounds on the motility of rat spermatozoa from the caput epididymidis.
Effects of carnitine and some related compounds on the motility of rat spermatozoa from the caput epididymidis.
复制标题
肉碱和一些相关化合物对大鼠附睾头精子活力的影响。
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
B. Setchell
中科院分区：
文献类型：
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作者：
B. T. Hinton;D. Brooks;H. Dott;B. Setchell
用显微穿刺法从大鼠附睾头收集精子，用含有肉毒碱或相关化合物的生理盐水稀释后测定其活力。L（+）-肉毒碱稀释后2分钟，引起一个短暂的刺激活动的精子与低初始活动。对具有高初始活动力的精子无刺激作用。D-异构体在2分钟后抑制具有高初始运动性的精子的运动性，并且所有测试的化合物在稀释后20分钟时似乎抑制具有高初始运动性的精子的运动性。乙酰-L-肉碱和乙酰-D-肉碱能刺激初始活动力低的精子的活动力。这项研究表明，肉毒碱可能是重要的精子的运动潜力的发展，也保持成熟的精子在静止状态。
Spermatozoa were collected from the rat caput epididymidis by micropuncture and their motility assessed after dilution in physiological saline containing carnitine or related compounds. L(+)-Carnitine caused, 2 min after dilution, a transient stimulation of the motility of spermatozoa with low initial motility. No stimulatory effects were seen on spermatozoa which had high initial motility. The D-isomer inhibited the motility of spermatozoa with high initial motility after 2 min and all compounds tested appeared to inhibit, at 20 min after dilution, the motility of spermatozoa with high initial motility. Acetyl-L-carnitine and acetyl-D-carnitine stimulated the motility of spermatozoa with low initial motility. This study suggests that carnitine may be important in the development by spermatozoa of the potential for motility and also to maintain mature spermatozoa in a quiescent state.