Peripheral and Central Auditory Dysfunction Induced by Occupational Exposure to Organic Solvents
Peripheral and Central Auditory Dysfunction Induced by Occupational Exposure to Organic Solvents
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DOI：
10.1097/jom.0b013e3181bae17c
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发表时间：
2009-10-01
影响因子：
3.2
通讯作者：
Rabinowitz, Peter M.
中科院分区：
文献类型：
--
作者：
Fuente, Adrian;Slade, Martin D.;Rabinowitz, Peter M.
目的：通过听力学成套测试，在职业上未暴露于高水平噪声的人群中检查溶剂暴露对听力功能的影响。方法：对某涂料厂110名工人进行调查。工厂的工作被分为三个不同的溶剂暴露水平。使用测试组合评估听力状态，包括纯音听阈（0.5-8 kHz）、高频听阈（12和16 kHz）以及通过双耳两分测试测量的双耳两分听力。建立多元线性回归模型，以探讨溶剂暴露与每种听力结果之间的可能关联。结果如下：溶剂暴露与三种听力结果之间存在显著相关性，协变量如年龄、性别、种族和民族也与所研究的听力结果显著相关。结论：职业性溶剂暴露可引起外周和中枢听觉功能障碍。两耳分指试验似乎是检测与溶剂暴露相关的中枢听觉功能障碍的一种合理工具。听力损失预防计划可以使用此工具来监测溶剂暴露工人的听力。（J Occup Environ Med.2009;51：1202-1211）
Objective: To examine the effects of solvent exposure on hearing function, through an audiological test battery, in a population not occupationally exposed to high levels of noise. Methods: One hundred ten workers from a coating factory were studied. jobs at the factory were divided into three different levels of solvent exposure. Hearing status was assessed with a test battery including pure-tone hearing thresholds (0.5-8 kHz), high-frequency hearing thresholds (12 and 16 kHz), and dichotic listening measured through dichotic digits test. Multiple linear regression models were created to explore possible association between solvent exposure and each of the hearing outcomes. Results: Significant associations between solvent exposure and the three hearing outcomes were found. Covariates such as age, gender, race, and ethnicity were also significantly associated with the studied hearing outcomes. Conclusions: Occupational exposure to solvents may induce both peripheral and central auditory dysfunction. The dichotic digits test seems as a sensible tool to detect central auditory dysfunction associated with solvent exposure. Hearing loss prevention programs may use this tool to monitor hearing in solvent-exposed workers. (J Occup Environ Med. 2009;51:1202-1211)