Increased intrathecal TGF-β1, but not IL-12, IFN-γ and IL-10 levels in Alzheimer's disease patients
Increased intrathecal TGF-β1, but not IL-12, IFN-γ and IL-10 levels in Alzheimer's disease patients
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DOI：
10.1007/s10072-006-0562-6
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发表时间：
2006-04-01
影响因子：
3.3
通讯作者：
Ferrero, P
中科院分区：
文献类型：
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作者：
Rota, E;Bellone, G;Ferrero, P
炎症反应已被假设参与原发性痴呆，尤其是阿尔茨海默病（AD）的发病机制。本研究旨在评估痴呆患者配对CSF和血清中的白细胞介素（IL）-12和一组相关细胞因子水平。IL-12检测了30例疑似阿尔茨海默病（PrAD）患者、57例其他痴呆症患者（包括疑似血管性痴呆（PrVD）、帕金森病（PD）和正常压力脑积水（NPH））、10例正常压力脑积水（PD）患者、10例正常压力脑积水（NPH）患者和10例正常压力脑积水（NPH）患者的外周血白细胞介素（IL）（p70异二聚体和总IL-12 p40链）、干扰素（IFN）-γ、IL-10和转化生长因子（TGF）-β 1水平。和25名认知正常的对照组。在IL-12、IFN-γ和IL-10浓度不变的情况下，与对照组和PrVD组相比，PrAD组TGF-β 1的平均CSF水平和相应的TGF-β 1指数（但非血清水平）显著升高，而与NPH和PD组相比无差异。我们的研究结果支持TGF-β 1系统在AD中的病理生理作用。
An inflammatory response has been hypothesised to be involved in the pathogenesis of primary dementias, above all Alzheimer's disease (AD). This study was aimed at evaluating interleukin (IL)-12 and a panel of related cytokine levels in paired CSF and sera of demented patients. IL-12 (p70 heterodimer and total IL-12 p40 chain), interferon (IFN)-gamma, IL-10 and transforming growth factor (TGF)-beta 1 levels were measured in 30 patients with probable Alzheimer's disease (PrAD), 57 patients with other dementing disorders, including probable vascular dementia (PrVD), Parkinson's disease (PD) and normal pressure hydrocephalus (NPH), and 25 cognitively normal control subjects. In the presence of unchanged concentrations of IL-12, IFN-gamma and IL-10, the mean CSF level of TGF-beta 1 and the correspondent TGF-beta 1 index, but not the serum level, were significantly increased in PrAD compared to controls and PrVD, whereas no difference was found vs. NPH and PD. Our results support the pathophysiological role of TGF-beta 1 system in AD.