Impaired Wound Healing Predisposes Obese Mice to Severe Influenza Virus Infection
Impaired Wound Healing Predisposes Obese Mice to Severe Influenza Virus Infection
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DOI：
10.1093/infdis/jir729
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发表时间：
2012-01-15
影响因子：
6.4
通讯作者：
Schultz-Cherry, Stacey
中科院分区：
文献类型：
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作者：
O'Brien, Kevin B.;Vogel, Peter;Schultz-Cherry, Stacey
肥胖首次成为2009年严重流感大流行感染的风险因素。鉴于肥胖症的增加，有必要了解这一人群不良预后的潜在机制。在这些研究中，我们检测了肥胖小鼠大流行性流感病毒的严重程度，并评估了抗病毒效果。我们发现，基因和饮食诱导的肥胖小鼠感染2009年甲型H1N1流感病毒亚型或1968年H3N2亚型毒株更有可能增加死亡率和与伤口修复受损和随后的肺水肿相关的肺部病理。用奥司他韦进行抗病毒治疗可提高肥胖小鼠的存活率。总的来说，这些研究表明，肥胖动物肺部伤口修复受损可能导致严重的流感病毒感染。在肥胖的情况下，可能需要其他预防和控制流感的方法。
For the first time, obesity appeared as a risk factor for developing severe 2009 pandemic influenza infection. Given the increase in obesity, there is a need to understand the mechanisms underlying poor outcomes in this population. In these studies, we examined the severity of pandemic influenza virus in obese mice and evaluated antiviral effectiveness. We found that genetically and diet-induced obese mice challenged with either 2009 influenza A virus subtype H1N1 or 1968 subtype H3N2 strains were more likely to have increased mortality and lung pathology associated with impaired wound repair and subsequent pulmonary edema. Antiviral treatment with oseltamivir enhanced survival of obese mice. Overall, these studies demonstrate that impaired wound lung repair in the lungs of obese animals may result in severe influenza virus infection. Alternative approaches to prevention and control of influenza may be needed in the setting of obesity.