Phosphoethanolamine methyltransferases in phosphocholine biosynthesis: functions and potential for antiparasite therapy.
Phosphoethanolamine methyltransferases in phosphocholine biosynthesis: functions and potential for antiparasite therapy.
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磷酸胆碱生物合成中的磷酸乙醇胺甲基转移酶：抗寄生虫治疗的功能和潜力。
DOI：
10.1111/j.1574-6976.2011.00267.x
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发表时间：
2011-07
影响因子：
11.3
通讯作者：
Ben Mamoun C
中科院分区：
文献类型：
--
作者：
Bobenchik AM;Augagneur Y;Hao B;Hoch JC;Ben Mamoun C
S-腺苷-L-甲硫氨酸依赖性甲基转移酶代表催化甲基从甲基供体S-腺苷-L-甲硫氨酸转移到大量生物活性大分子和小分子的氮、氧、硫或碳原子的不同酶组。这些修饰在基因表达、信号传导、核分裂和代谢等多种生物学功能的调节中发挥重要作用。磷酸乙醇胺N-甲基转移酶催化的磷酸乙醇胺的三步S-腺苷-L-蛋氨酸依赖性甲基化形成磷酸胆碱已成为一些真核生物中主要磷脂（磷脂酰胆碱）合成的重要生化步骤。磷酸乙醇胺N-甲基转移酶已在线虫、植物、非洲爪蛙、斑马鱼、佛罗里达文昌鱼、变形菌和人类疟疾寄生虫中鉴定。迄今为止积累的数据表明这些酶在生长和发育中的重要作用。本文综述了这些酶的生物化学和遗传特性的研究，并讨论了它们的进化和它们作为开发抗寄生虫感染疗法的目标的适用性，以及在生物工程中开发营养和抗应激植物。
S-adenosyl-L-methionine-dependent methyltransferases represent a diverse group of enzymes that catalyze the transfer of a methyl group from a methyl donor S-adenosyl-L-methionine to nitrogen, oxygen, sulfur or carbon atoms of a large number of biologically active large and small molecules. These modifications play a major role in the regulation of various biological functions such as gene expression, signaling, nuclear division and metabolism. The three-step S-adenosyl-L-methionione-dependent methylation of phosphoethanolamine to form phosphocholine catalyzed by phosphoethanolamine N-methyltransferases has emerged as an important biochemical step in the synthesis of the major phospholipid, phosphatidylcholine, in some eukaryotes. Phosphoethanolamine N-methyltransferases have been identified in nematodes, plants, African clawed frogs, zebrafish, the Florida lancelet, proteobacteria and human malaria parasites. Data accumulated thus far suggest an important role for these enzymes in growth and development. This review summarizes published studies on the biochemical and genetic characterization of these enzymes, and discusses their evolution and their suitability as targets for the development of therapies against parasitic infections, as well as in bioengineering for the development of nutritional and stress-resistant plants.
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影响因子：
--
作者：
Bobenchik, April M.;Choi, Jae-Yeon;Ben Mamoun, Choukri
通讯作者：
Ben Mamoun, Choukri
影响因子：
7.4
作者：
DATKO, AH;MUDD, SH
通讯作者：
MUDD, SH
影响因子：
4.1
作者：
Brendza, Katherine M.;Haakenson, William;Jez, Joseph M.
通讯作者：
Jez, Joseph M.
影响因子：
7.4
作者：
Bolognese, CP;McGraw, P
通讯作者：
McGraw, P
影响因子：
4
作者：
Lochnit, G;Bongaarts, R;Geyer, R
通讯作者：
Geyer, R