Genetic variations of bile salt transporters.
Genetic variations of bile salt transporters.
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DOI：
10.1016/j.ddtec.2014.03.006
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发表时间：
2014-06-01
期刊：
影响因子：
--
通讯作者：
Haussinger, Dieter
中科院分区：
文献类型：
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作者：
Kubitz, Ralf;Droge, Carola;Haussinger, Dieter
胆盐转运体通过胆盐的物理化学或信号特性直接或间接影响生物过程。肝脏、胆道、小肠和肾脏极化上皮细胞中摄取和流出转运体的协调作用决定了体内不同部位的胆盐浓度。胆盐转运体的遗传变异导致不同严重程度的临床相关表型，从药物性肝损伤的易感性到快速进展的终末期肝病。本文综述了BSEP、NTCP、ASBT和OSTalpha/beta等胆汁盐转运体遗传变异对胆汁盐转运体的影响，并讨论了转运体分析的方法。
Bile salt transporters directly or indirectly influence biological processes through physicochemical or signalling properties of bile salts. The coordinated action of uptake and efflux transporters in polarized epithelial cells of the liver, biliary tree, small intestine and kidney determine bile salt concentrations in different compartments of the body. Genetic variations of bile salt transporters lead to clinical relevant phenotypes of varying severity ranging from a predisposition for drug-induced liver injury to rapidly progressing end-stage liver disease. This review focuses on the impact of genetic variations of bile salt transporters including BSEP, NTCP, ASBT and OSTalpha/beta and discusses approaches for transporter analysis.