Highly sensitive ratiometric fluorescence detection of tetracycline residues in food samples based on Eu/Zr-MOF.
Highly sensitive ratiometric fluorescence detection of tetracycline residues in food samples based on Eu/Zr-MOF.
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DOI：
10.1016/j.foodchem.2023.137717
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发表时间：
2023-10
期刊：
影响因子：
8.8
通讯作者：
Lei Zhang;Yuxin He;Yue Wu;Jieyuan Zhang;Siqiao Li;Zhengwei Zhang
中科院分区：
文献类型：
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作者：
Lei Zhang;Yuxin He;Yue Wu;Jieyuan Zhang;Siqiao Li;Zhengwei Zhang
开发一种简单、快速、灵敏的抗生素残留监测方法对维护食品安全至关重要。本文以四环素（TC）为研究对象，研制了一种基于双金属有机骨架的比率荧光探针（Eu/Zr-MOF）。通过Eu 3+和Zr 4+与2-APDC的配位反应，合成了Eu/Zr-MOF，其具有葡萄状团簇形貌和430 nm/616 nm的双发射荧光。基于内过滤效应（IFE），在430 nm处观察到显著的荧光猝灭，而在616 nm处仅发生轻微变化。比率传感提供了两个宽的线性范围（0.5-8 μg/mL; 10-60 μg/mL）和低检测限（26.7 ng/mL）。方法用于猪肉和水样中总胆固醇的测定。荧光传感器具有设计简单、响应速度快、灵敏度高等优点，为食品中TC污染的安全性评价提供了一种很有前途的手段。
The development of a simple, rapid, and sensitive method for monitoring antibiotic residues is crucial for maintaining food safety. Herein, a ratiometric fluorescence probe based on bimetallic organic framework (Eu/Zr-MOF) was developed for the detection of tetracycline (TC). The Eu/Zr-MOF was synthesized by the coordination of Eu3+and Zr4+with 2-APDC, which exhibited a grape-like cluster morphology and dual-emitting fluorescence at 430 nm/616 nm. Based on the internal filtering effect (IFE), significant fluorescence quenching was observed at 430 nm, whereas only slight changes occurred at 616 nm. The ratiometric sensing offered two broad linear ranges (0.5–8 μg/mL; 10–60 μg/mL) and a low detection limit (26.7 ng/mL). The proposed method was applied to the determination of TC in pork and water samples. Fluorescent sensors have the advantages of simple design, fast response, and high sensitivity, thus providing a promising means for evaluating the safety of food contaminated with TC.