Anchoring of epithelia to underlying connective tissue: evidence of frayed ends of collagen fibrils directly merging with meshwork of lamina densa.
Anchoring of epithelia to underlying connective tissue: evidence of frayed ends of collagen fibrils directly merging with meshwork of lamina densa.
复制标题
上皮细胞锚定于下面的结缔组织：胶原原纤维磨损末端直接与致密层网状结构融合的证据。
DOI：
10.1093/oxfordjournals.jmicro.a051112
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
T. Hayashi
中科院分区：
文献类型：
--
作者：
E. Adachi;T. Hayashi
我们研究了小鼠胰腺、人胎盘和猴口腔粘膜的上皮-上皮下连接。在小鼠胰腺中，在快速冷冻、深蚀刻、旋转复制的显微照片中，胶原原纤维靠近致密层并磨损成两个或三个亚原纤维与致密层网合并。在胎盘绒毛中，一些胶原纤维走向滋养细胞，可能与致密层融合。在口腔粘膜中，一些胶原纤维弯曲成上皮细胞，穿过锚定纤维网络，与致密层的基底面明显融合。结合从V型胶原蛋白和从V型和I型胶原蛋白的混合原纤维重构的胶原原纤维的形态以及这里呈现的结果，我们提出胶原原纤维与致密层的直接连接可能是稳定上皮组织的普遍存在的锚定系统。
We examined the epithelial-subepithelial junction of mouse pancreas, human placenta and monkey oral mucosa. In mouse pancreas, in quick-freeze, deep-etch, rotary-replicated micrographs, collagen fibrils ran close to the lamina densa and frayed out into two or three subfibrils merging with lamina densa meshwork. In placental villi, some collagen fibrils ran toward trophoblasts and probably merging with lamina densa. In oral mucosa, some collagen fibrils curved to epithelial cells, passed through the anchoring fibril network and apparently merged with the basal surface of lamina densa. Together with the morphology of reconstituted collagen fibrils from type V collagen and hybrid fibrils from type V and type I collagen and the results presented here, we propose that a direct connection of collagen fibrils with lamina densa could be a ubiquitous anchoring system to stabilize epithelial tissues.