POLYAMINES ENHANCE READTHROUGH OF THE UGA TERMINATION CODON IN A MAMMALIAN MESSENGER-RNA
POLYAMINES ENHANCE READTHROUGH OF THE UGA TERMINATION CODON IN A MAMMALIAN MESSENGER-RNA
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DOI：
10.1007/bf00330661
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发表时间：
1983-01-01
期刊：
影响因子：
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通讯作者：
VONDERHAAR, RA
中科院分区：
文献类型：
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作者：
HRYNIEWICZ, MM;VONDERHAAR, RA
多胺亚精胺和精胺刺激兔β-半乳糖苷酶的UGA终止密码子的通读。珠蛋白mRNA在兔网织红细胞无细胞系统中翻译时的表达。另一种主要的多胺腐胺没有这种作用。多胺诱导的通读对UGA是特异性的，UGA是α-谷氨酰胺的UAA终止密码子。在亚精胺或精胺存在下，珠蛋白mRNA不被通读，并且一般的翻译误读错误不发生。这种影响的可能机制和一些可能的监管影响进行了讨论。
The polyamines spermidine and spermine stimulate the readthrough of the UGA termination codon of rabbit .beta.-globin mRNA when it is translated in a rabbit reticulocyte cell-free system. The other major polyamine, putrescine, does not show this effect. The polyamine induced readthrough is specific for UGA as the UAA termination codon of .alpha.-globin mRNA is not read through and general translational misreading errors are not occurring in the presence of spermidine or spermine. The probable mechanism of this effect and some possible regulatory implications are discussed.