A SURVEY OF PRIMATE SERA FOR ANTIBODIES TO VIRUSES OF HUMAN AND SIMIAN ORIGIN
A SURVEY OF PRIMATE SERA FOR ANTIBODIES TO VIRUSES OF HUMAN AND SIMIAN ORIGIN
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DOI：
10.1093/oxfordjournals.aje.a120765
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发表时间：
1967-01-01
影响因子：
5
通讯作者：
KIM, CS
中科院分区：
文献类型：
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作者：
KALTER, SS;RATNER, J;KIM, CS
研究了来自灵长类动物（人、大猩猩、黑猩猩、猩猩、狒狒、长尾猴、恒河猴和pata）的不同属和种的血清中是否存在针对人类和猿源的选定病毒的抗体。最受关注的是从圈养狒狒中获得的血清，以及从非洲肯尼亚原生栖息地捕获的狒狒立即流血的的血清。本研究的目的不仅是熟悉各种灵长类动物的抗体谱，而且还研究这些动物作为人类疾病实验模型的可能性。这些研究的结果表明：某些病毒的地理分布很广;尽管存在物种特异性，但研究的灵长类动物中存在许多人类和猿类病毒的抗体（即，它们似乎在“天然”宿主范围上有所不同）;某些病原体抗体的高发生率表明自然界中存在储存库;狒狒的黄热病疫苗接种表明所用疫苗效力低; SV 5病毒虽然最初从猴子身上分离出来，但很可能是一种人类粘病毒，因为它只在与人类接触的动物中流行;而这里所报道的关于狒狒以及其他非人灵长类动物的数据对于在实验使用之前开发动物的病毒谱是有价值的。
Sera from various genera and species of primates (man, gorilla, chimpanzee, orangutan, gibbon, baboon, vervet, rhesus and patas) were studied for the presence or absence of antibody to selected viruses of human and simian origin. Greatest attention was given to sera obtained from baboons maintained in captivity, as well as from baboons bled immediately on capture in their native habitat in Kenya, Africa. The purpose of this study was not only to become familiar with the antibody spectrum of various primates but also to investigate these animals as possible experimental models of human diseases. As a result of these studies, it became apparent that: there is a wide geographic distribution of certain viruses; antibodies to many human and simian viruses are present in the primates studied although there is a suggestion of species specificity (that is, they seem to differ in their "natural" host range); the high incidence of antibody to certain agents suggests a reservoir in nature; yellow fever vaccination of baboons indicates the vaccines used were of low potency; SV5 virus, although originally isolated from monkeys, may very well be a human myxovirus since it is prevalent only among animals with human contact; and data such as reported here on baboons as well as other nonhuman primates are of value in order to develop a virus profile of the animal before its experimental employment.