Investigating Default Mode and Sensorimotor Network Connectivity in Amyotrophic Lateral Sclerosis.
Investigating Default Mode and Sensorimotor Network Connectivity in Amyotrophic Lateral Sclerosis.
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DOI：
10.1371/journal.pone.0157443
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Kalra S
中科院分区：
文献类型：
--
作者：
Chenji S;Jha S;Lee D;Brown M;Seres P;Mah D;Kalra S
肌萎缩侧索硬化症 (ALS) 是一种神经退行性疾病，其特征是大脑运动皮层的上运动神经元 (UMN) 以及脑干和脊髓的下运动神经元 (LMN) 退化。大脑变化会导致功能磁共振成像 (fMRI) 捕获的大脑活动产生差异，包括称为静息状态网络 (RSN) 的区域之间发生的自发和同时活动。 ALS 中观察到的进行性神经退行性变可能会导致 RSN 破坏，从而提供对疾病过程的深入了解。先前的研究报告了 ALS 中 RSN 功能连接增加、减少或未改变的相互矛盾的发现，并且没有报告 UMN 变化对 RSN 连接的贡献。我们旨在通过在 21 名 ALS 患者和 40 名年龄匹配的健康志愿者中探索两个网络，即默认模式网络 (DMN) 和感觉运动网络 (SMN) 来弥补这一差距。 UMN 评分将患者分为 UMN+ 组和 UMN- 组。受试者在 4.7 特斯拉的高场 MRI 上接受静息态 fMRI 扫描。比较受试者组之间的 DMN 和 SMN 变化。评估了连接性和临床测量指标之间的相关性，例如 ALS 功能评定量表修订版 (ALSFRS-R)、疾病进展率、症状持续时间、UMN 评分和手指敲击。患者和对照组之间的静息状态网络不存在显着的组间差异，对 UMN 负担程度的依赖性也是如此。然而，在残疾程度较重且进展速度较快的患者中，DMN 连接性增加，而在运动障碍较严重的患者中，SMN 连接性减少。这些关联模式与支持抑制性中间神经元丧失的文献一致。
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative condition characterized by degeneration of upper motor neurons (UMN) arising from the motor cortex in the brain and lower motor neurons (LMN) in the brainstem and spinal cord. Cerebral changes create differences in brain activity captured by functional magnetic resonance imaging (fMRI), including the spontaneous and simultaneous activity occurring between regions known as the resting state networks (RSNs). Progressive neurodegeneration as observed in ALS may lead to a disruption of RSNs which could provide insights into the disease process. Previous studies have reported conflicting findings of increased, decreased, or unaltered RSN functional connectivity in ALS and do not report the contribution of UMN changes to RSN connectivity. We aimed to bridge this gap by exploring two networks, the default mode network (DMN) and the sensorimotor network (SMN), in 21 ALS patients and 40 age-matched healthy volunteers. An UMN score dichotomized patients into UMN+ and UMN- groups. Subjects underwent resting state fMRI scan on a high field MRI operating at 4.7 tesla. The DMN and SMN changes between subject groups were compared. Correlations between connectivity and clinical measures such as the ALS Functional Rating Scale—Revised (ALSFRS-R), disease progression rate, symptom duration, UMN score and finger tapping were assessed. Significant group differences in resting state networks between patients and controls were absent, as was the dependence on degree of UMN burden. However, DMN connectivity was increased in patients with greater disability and faster progression rate, and SMN connectivity was reduced in those with greater motor impairment. These patterns of association are in line with literature supporting loss of inhibitory interneurons.