A STUDY OF ACNE TREATMENTS AS RISK-FACTORS FOR SKIN-CANCER OF THE HEAD AND NECK
A STUDY OF ACNE TREATMENTS AS RISK-FACTORS FOR SKIN-CANCER OF THE HEAD AND NECK
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DOI：
10.1111/j.1365-2133.1991.tb14169.x
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发表时间：
1991-10-01
影响因子：
10.3
通讯作者：
LANE, P
中科院分区：
文献类型：
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作者：
HOGAN, DJ;TO, T;LANE, P
对面部皮肤癌的风险因素进行了回顾性问卷调查，重点是痤疮和既往痤疮治疗，特别是过氧苯甲酰制剂的使用。964例有效率为90.9%，3856例对照有效率为79.9%。痤疮和使用任何痤疮药物与面部皮肤癌风险之间没有关联。皮肤癌病例比对照组更有可能使用光疗或日光浴床（P = 0.024），更有可能在诊断前接受放射治疗（P = 0.001）。广义线性交互模型确定的主要风险因素是皮肤癌家族史（比值比2.68; 95%置信区间2.15，3.34），浅色皮肤（1.54; 1.25，1.89），容易晒伤（1.43; 1.16，1.76）和爱尔兰，苏格兰，斯堪的纳维亚或德国母亲（1.33; 1.11，1.59）。
A retrospective questionnaire was conducted as to the risk factors for facial skin cancer with emphasis on acne and past treatments for acne, in particular use of benzoyl peroxide preparations. The response rate was 90.9% for 964 cases and 79.9% for 3856 controls. There was no association between acne and the use of any acne medication for the risk of facial skin cancer. Cases of skin cancer were significantly more likely to have used phototherapy or sunbeds than the controls (P = 0.024), and more likely to have had radiotherapy prior to diagnosis (P = 0.001). The major risk factors as determined by generalized linear interactive modelling were family history of skin cancer (odds ratio 2.68; 95% confidence interval 2.15, 3.34), light skin (1.54; 1.25, 1.89), sunburning easily (1.43; 1.16, 1.76) and Irish, Scottish, Scandinavian or German mothers (1.33; 1.11, 1.59).