A Model of Epithelial Invagination Driven by Collective Mechanics of Identical Cells
A Model of Epithelial Invagination Driven by Collective Mechanics of Identical Cells
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DOI：
10.1016/j.bpj.2012.07.018
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发表时间：
2012-09-05
影响因子：
3.4
通讯作者：
Ziherl, Primoz
中科院分区：
文献类型：
--
作者：
Brezavscek, Ana Hocevar;Rauzi, Matteo;Ziherl, Primoz
我们提出了一个类似于果蝇早期胚胎的管状上皮的2D力学模型。该模型由单层相同的细胞组成，其能量与细胞皮质的张力有关。根据细胞顶端、底部和外侧的相对紧张度、组织厚度和外部约束程度，上皮横截面的最小能量状态包括圆形和一系列向内弯曲的形状。有些溶液的特征是只有一个深凹槽，这表明由具有相同机械性能的细胞组成的上皮可以折叠。这与在某些果蝇突变体的胚胎中看到的是一致的。为了确保内折发生在预定的上皮部分，我们通过增加细胞子集的横截面积来扩展模型，这与在野生型胚胎中观察到的一致。上皮细胞参数的这种变化足以使其在特定位置折叠。该模型探索了以前未被测试的组织内陷的最小条件，并且缺乏准确描述果蝇体内情况所需的特异性。
We propose a 2D mechanical model of a tubular epithelium resembling the early Drosophila embryo. The model consists of a single layer of identical cells with energy associated with the tension of cell cortex. Depending on the relative tersion of the apical, basal, and lateral sides of the cells, tissue thickness, and the degree of external constraint, the minimal-energy states of the epithelial cross section include circular shapes as well as a range of inward-buckled shapes. Some of the solutions are characterized by a single deep groove, which shows that an epithelium consisting of cells of identical mechanical properties can infold. This is consistent with what is seen in embryos of certain Drosophila mutants. To ensure that the infolding occurs at a predetermined section of the epithelium, we extend the model by increasing the cross-sectional area of a subset of cells, which is consistent with observations in wild-type embryos. This variation of cell parameters across the epithelium is sufficient to make it fold at a specific site. The model explores previously untested minimal conditions for tissue invagination and is devoid of specificity needed to accurately describe an in vivo situation in Drosophila.