Histidine-Rich Protein 2 Plasma Levels Predict Progression to Cerebral Malaria in Malawian Children With Plasmodium falciparum Infection
Histidine-Rich Protein 2 Plasma Levels Predict Progression to Cerebral Malaria in Malawian Children With Plasmodium falciparum Infection
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DOI：
10.1093/infdis/jit176
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发表时间：
2013-08-01
影响因子：
6.4
通讯作者：
Seydel, Karl B.
中科院分区：
文献类型：
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作者：
Fox, Lindsay L.;Taylor, Terrie E.;Seydel, Karl B.
一些患有单纯性疟疾的儿童尽管接受了适当的治疗，仍会发展为脑型疟疾；提前识别他们可能会改善他们的护理。本研究的目的是确定疟疾蛋白 HRP2（富含组氨酸的蛋白 2）的血浆浓度是否可以达到此目的。病例和对照是患有无并发症疟疾的儿童；病例（n = 25）患上了脑型疟疾，而对照组（n = 125）则没有。这些病例的平均血浆 HRP2 浓度显着较高，并且确定了可以预测疾病进展的 HRP2 截止值（敏感性和特异性，各为 88%）。 HRP2 的定量测量可能是一种有用的筛选工具。
Some children with uncomplicated malaria progress to cerebral malaria despite appropriate treatment; identifying them in advance might improve their care. The objective of this study was to determine if plasma concentrations of a malaria protein, HRP2 (histidine-rich protein 2) would serve this purpose. Cases and controls were children presenting with uncomplicated malaria; the cases (n = 25) developed cerebral malaria, and the controls (n = 125) did not. Mean plasma HRP2 concentrations were significantly higher in the cases, and an HRP2 cutoff was identified that could predict disease progression (sensitivity and specificity, 88% for each). Quantitative measurements of HRP2 may be a useful screening tool.