Complex reconfiguration of DNA nanostructures.
Complex reconfiguration of DNA nanostructures.
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DOI：
10.1002/anie.201402437
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发表时间：
2014-07-14
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核酸已被用于创建不同的合成结构和动力学系统。支点介导的链置换使得复杂电路、马达和分子计算机的构建成为可能。然而，演示复杂的结构重构仍然具有挑战性，其中结构从起始形状改变为另一个任意规定的形状。为了解决这一挑战，我们已经开发了一种通用的结构重构方法，利用单链DNA瓦片和砖块结构的模块化互连架构。移除一个组成股揭示了相邻股上新暴露的立足点，使我们能够移除连接的组成股区域，而无需使用预先设计的外部立足点修改股。使用这种方法，我们已经重新配置成不同的规定形状的二维DNA矩形画布。我们也使用这种方法来重新配置一个三维DNA立方体。
Nucleic acids have been used to create diverse synthetic structural and dynamic systems. Toehold-mediated strand displacement has enabled the construction of sophisticated circuits, motors, and molecular computers. Yet it remains challenging to demonstrate complex structural reconfiguration in which a structure changes from a starting shape to another arbitrarily prescribed shape. To address this challenge, we have developed a general structural reconfiguration method that utilizes the modularly inter-connected architecture of single-stranded DNA tile and brick structures. The removal of one component strand reveals a newly exposed toehold on a neighboring strand, allowing us to remove regions of connected component strands without needing to modify the strands with predesigned external toeholds. Using this method, we have reconfigured a two-dimensional DNA rectangle canvas into diverse prescribed shapes. We also used this method to reconfigure a three-dimensional DNA cuboid.