Subjective sleep complaints in pediatric depression: A controlled study and comparison with EEG measures of sleep and waking
Subjective sleep complaints in pediatric depression: A controlled study and comparison with EEG measures of sleep and waking
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DOI：
10.1097/01.chi.0000179057.54419.17
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发表时间：
2005-11-01
影响因子：
13.3
通讯作者：
Ryan, ND
中科院分区：
文献类型：
--
作者：
Bertocci, MA;Dahl, RE;Ryan, ND
目的：重度抑郁症的儿童（MDD）经常抱怨睡眠障碍；但是，多个学位研究未能找到这些干扰的客观证据。本文研究了MDD儿童和健康对照儿童的主观睡眠报告，重点是比较主观和客观的睡眠度量。方法：拥有MDD的五十一个受试者和42名8-17岁的健康受试者参加了一项全面的心理生物学研究，包括三个晚上的脑电图记录。每天早晨，受试者都会主观地评估睡眠后睡眠形式，然后将其与他们的多个学术研究进行了比较。结果：沮丧的受试者报告说，在四个尺度上睡眠明显较差：主观的睡眠质量，可感知的觉醒数量，估计的钟表觉醒和可感知的醒来。与这些主观的抱怨相比，客观的脑电图措施表明，与对照组相比，抑郁样本中没有睡眠干扰的证据。此外，探索性分析的重点是最大的主观睡眠障碍的抑郁症受试者子集，这表明，矛盾的是，就脑电图觉醒的数量和客观干扰而言，睡眠明显更好。结论：尽管抑郁儿童中主观睡眠申诉的临床证据，但我们的脑电图措施几乎没有证据表明这些看法的客观基础。这些发现引发了有关与早发性抑郁症相关的睡眠投诉性质的挑衅性问题。
Objective: Children with major depressive disorder (MDD) often complain of sleep disturbances; however, polysomnographic studies have failed to find objective evidence of these disturbances. This article examines subjective sleep reports of children with MDD and healthy controls focusing on comparing subjective and objective sleep measures. Method: Fifty-one subjects with MDD and 42 healthy subjects, 8-17 years old, participated in a comprehensive psychobiologic study including three nights of EEG sleep recording. Each morning, subjects completed a postsleep form subjectively rating their sleep, which was then compared with their polysomnographic studies. Results: Depressed subjects reported significantly worse sleep on four scales: subjective sleep quality, perceived number of awakenings, estimated minutes awake, and perceived ease of waking. In contrast to these subjective complaints, objective EEG measures indicated no evidence of disturbed sleep in the depressed sample compared to controls. Furthermore, exploratory analyses focusing on the subset of depressed subjects with the greatest subjective sleep disturbance showed, paradoxically, significantly better sleep in terms of the number of EEG awakenings and objective disturbances. Conclusions: Despite clinical evidence of subjective sleep complaints in depressed children, our EEG measures showed little evidence to indicate an objective basis for these perceptions. These findings raise provocative questions regarding the nature of sleep complaints associated with early-onset depression.