Structural analogues of the bimetallic reaction center in acetyl CoA synthase: A Ni-Ni model with bound CO
Structural analogues of the bimetallic reaction center in acetyl CoA synthase: A Ni-Ni model with bound CO
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DOI：
10.1021/ja035606c
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发表时间：
2003-07-23
影响因子：
15
通讯作者：
Wilson, SR
中科院分区：
文献类型：
--
作者：
Linck, RC;Spahn, CW;Wilson, SR
Models for the active site of the acetyl CoA synthase (ACS) were synthesized by attachment of Cu+and Ni(0) to nickel diaminodithiolate (S2N2) and diamidodithiolate (S2N2‘) complexes. The Ni−Ni species form stable CO adducts, i.e., [{(CO)2Ni}{NiS2N2‘}]2-, whereas the Cu-NiS2N2and Cu-NiS2N2‘ models do not. These results provide supporting evidence for a biological role for reduced nickel in ACS.
