Effect of interpregnancy interval on adverse perinatal outcomes - a national study
Effect of interpregnancy interval on adverse perinatal outcomes - a national study
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DOI：
10.1016/j.contraception.2009.06.006
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发表时间：
2009-12-01
期刊：
影响因子：
2.9
通讯作者：
Schimmel, Michael M.
中科院分区：
文献类型：
--
作者：
Grisaru-Granovsky, Sorina;Gordon, Ethel-Sherry;Schimmel, Michael M.
背景：有报道称，妊娠间期（IPI）会影响妊娠和分娩结局。我们在以色列进行了一项全国性的研究，以确定IPI对多个不良围产期outcomes.Study设计的影响：这个纵向队列研究使用出生证明的兄弟姐妹出生于同一个生物学母亲，至少有一个以前的出生和随后的单胎妊娠。不良妊娠结局包括早产、极早产、小于胎龄儿（SGA）、极SGA（VSGA）、早期新生儿死亡和严重先天性畸形。多变量logistic回归进行了每个outcome.Results：该研究包括440,838的846,845报告活产在以色列超过5年，排除了胎儿（32%），多胎出生（4.9%）和那些数据不完整（10.9%）。对于小于6个月的IPI，早产（OR=1.23）、SGA（OR=1.14）、VSGA（OR = 1.15）、早期新生儿死亡（OR=1.62）和先天性畸形（OR=1.14）的风险显著增加。间隔时间≥ 60个月者发生早产（OR=1.39）和VSGA（OR=1.16）的危险性较高。结论：IPI建议间隔时间≥ 11个月是改善围生儿多项不良结局的一种可行且低成本的方法。(C)2009年由Elsevier Inc.出版
Background: The interpregnancy interval (IPI) has been reported to influence the outcome of pregnancy and birth. We performed a national study in Israel to determine the impact of IPI on multiple adverse perinatal outcomes.Study Design: This longitudinal cohort study used birth certificates of siblings born to the same biological mother, with at least one previous birth and a subsequent singleton pregnancy. Adverse pregnancy outcomes included preterm delivery, very preterm birth, small for gestational age (SGA), very SGA (VSGA), early neonatal death and major congenital malformations. Multivariate logistic regression was performed for each outcome.Results: The study included 440,838 of a total of 846,845 reported live births in Israel over 5 years; excluded were primiparas (32%), multifetal births (4.9%) and those with incomplete data (10.9%). For IPIs shorter than 6 months, there were significantly increased risks for preterm birth (OR=1.23), SGA (OR=1.14), VSGA (OR=1.15), early neonatal death (OR=1.62) and congenital malformations (OR=1.14). Intervals of 60 months or longer had higher risks for preterm birth (OR=1.39) and VSGA (OR=1.16).Conclusion: Optimal IPI recommendation of >11 months is an accessible and low-cost means to improve multiple adverse perinatal outcomes. (C) 2009 Published by Elsevier Inc.