Content and composition of fatty acids in normal and inflamed gingival tissues
Content and composition of fatty acids in normal and inflamed gingival tissues
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DOI：
10.1016/j.plefa.2004.10.013
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发表时间：
2005-03-01
影响因子：
3
通讯作者：
Sahin, F
中科院分区：
文献类型：
--
作者：
Çiçek, Y;Özmen, I;Sahin, F
必需脂肪酸的平衡对身体健康和正常发育至关重要。必需脂肪酸（EFA）是前列腺素（PGs）、血栓烷和白三烯（LT）的前体。本临床研究的目的是测定多不饱和脂肪酸（PUFA）、单不饱和脂肪酸（MUFA）、饱和脂肪酸（SFA）的总脂肪酸水平以及发炎和正常牙龈组织的每种脂肪酸水平。本研究纳入了27例受试者。本文分析了19例牙龈炎症组织（纤维增生组织9例，周围巨细胞肉芽肿组织10例，正常牙龈组织8例）。组织学上评估炎症的特征。进行方差分析以评估组织间的差异。使用Sherlock微生物鉴定系统（MIS）软件（Microbial ID，纽瓦克，DE，USA）通过气相色谱法测定发炎的人牙龈组织和8个正常人牙龈组织样品中的组织的总细胞脂肪酸谱，所述软件具有真核细胞的FAME谱数据库。通过Sherlock微生物鉴定系统（MIS）或数据库气相色谱法（DGC）定量PUFA、MUFA和SFA。炎症牙龈组织（FH、PGCG）和健康牙龈组织中PUFA和MUFA的浓度差异有统计学意义（P
The balance of essential fatty acid is important for good health and normal development. Essential fatty acids (EFA) are the precursors of prostaglandins (PGs), thromboxanes and leukotrienes (LT). The aim of this clinical study was to determine the total fatty acid level of polyunsaturated fatty acids (PUFA), monounsaturated fatty acids (MUFA), saturated fatty acids (SFA) and each fatty acids level of inflamed and normal gingival tissues. Twenty-seven subjects were included the present study. Nineteen samples of inflamed human gingival tissue (nine of fibrous hyperplasia (FH), ten of peripheral giant cell granuloma (PGCG) and eight samples of normal human gingival tissue were analyzed. The characteristics of inflammation were assessed histologically. Variance analyses were performed to assess the differences among tissues. The total cellular fatty acid profiles of the tissues in inflamed human gingival tissue and in eight samples of normal human gingival tissue were determined by gas chromatography using Sherlock microbial identification system (MIS) software (Microbial ID, Newark, DE, USA) with a database of FAME profiles for eukary. PUFAs, MUFAs, and SFAs were quantified by Sherlock microbial identification system (MIS) or database gas chromatography (DGC). There were statistically significant differences between the concentrations in inflamed (FH, PGCG) and healthy gingival tissues for PUFA and MUFA (P