The effects of PDL-Ig on collagen-induced arthritis
The effects of PDL-Ig on collagen-induced arthritis
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DOI：
10.1007/s00296-009-1249-0
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发表时间：
2011-04-01
影响因子：
4
通讯作者：
Wu, Xiongwen
中科院分区：
文献类型：
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作者：
Wang, Guohua;Hu, Ping;Wu, Xiongwen
程序性死亡配体（PDL）是B7共刺激分子家族的新成员，可与活化的T细胞、B细胞和髓细胞上表达的程序性死亡1 （PD-1）特异性相互作用。II型胶原蛋白（CII）诱导的关节炎（CIA）是一种关节炎的实验模型，已被用于解剖人类类风湿关节炎的发病机制。本研究探讨了PDL-Ig对CIA的影响。通过临床关节炎评分和关节组织学评估，给予PDL-Ig可显著改善疾病。血清中IL-17和IL-23等促炎细胞因子的表达在PDL-Ig处理后降低。这些结果表明PDL-Ig通过抗炎作用和抑制CII对CIA的细胞增殖作用，提示PD-1-PDL通路可能参与CIA的发病机制，因此PDL-Ig可能是改善人类类风湿关节炎的有效疗法。
Programmed death ligand (PDL) is a new member of the B7 family of costimulatory molecules that specifically interacts with programmed death 1 (PD-1) expressed on activated T cells, B cells, and myeloid cells. Collagen II (CII)-induced arthritis (CIA) is an experimental model of arthritis that has been used to dissect the pathogenesis of human rheumatoid arthritis. In this study, we have investigated the effects of PDL-Ig on CIA. Administration of PDL-Ig significantly ameliorated the disease as assessed by clinical arthritis score and histology in the joints. Expression of proinflammatory cytokines, such as IL-17 and IL-23, in the serum was reduced by PDL-Ig treatment. These results showed a beneficial effect of PDL-Ig on CIA through anti-inflammatory actions and inhibition of cell proliferation in response to CII, suggesting that the PD-1-PDL pathway may be involved in the pathogenesis of CIA, and thus PDL-Ig may be a useful therapy for the improvement of human rheumatoid arthritis.