EXTRACELLULAR PROTEOLYSIS IN THE ADULT MURINE BRAIN
EXTRACELLULAR PROTEOLYSIS IN THE ADULT MURINE BRAIN
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DOI：
10.1172/jci116637
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发表时间：
1993-08-01
影响因子：
15.9
通讯作者：
VASSALLI, JD
中科院分区：
文献类型：
--
作者：
SAPPINO, AP;MADANI, R;VASSALLI, JD
纤溶酶原激活物是细胞外代谢的重要介质。在神经系统中，纤溶酶原激活剂被认为参与发育和再生期间细胞迁移所需的重塑事件。我们现在已经探索了成年小鼠中枢神经系统中纤溶酶原激活物/纤溶酶系统的表达。组织型纤溶酶原激活物由大多数脑区的神经元合成，而突出的组织型纤溶酶原激活物催化的蛋白水解仅限于离散区域，特别是海马和下丘脑。我们的观察结果表明，组织型纤溶酶原激活剂催化的蛋白水解在神经组织中不仅限于个体发育，但也可能有助于成人中枢神经系统的生理，例如通过影响神经元的可塑性和突触重组。鉴定在成人中枢神经系统中活跃的细胞外蛋白水解系统也可能有助于深入了解与细胞外蛋白沉积相关的神经退行性疾病的病因。
Plasminogen activators are important mediators of extracellular metabolism. In the nervous system, plasminogen activators are thought to be involved in the remodeling events required for cell migration during development and regeneration. We have now explored the expression of the plasminogen activator/plasmin system in the adult murine central nervous system. Tissue-type plasminogen activator is synthesized by neurons of most brain regions, while prominent tissue-type plasminogen activator-catalyzed proteolysis is restricted to discrete areas, in particular whithin the hippocampus and hypothalamus. Our observations indicate that tissue-type plasminogen activator-catalyzed proteolysis in neural tissues is not limited to ontogeny, but may also contribute to adult central nervous system physiology, for instance by influencing neuronal plasticity and synaptic reorganization. The identification of an extracellular proteolytic system active in the adult central nervous system may also help gain insights into the pathogeny of neurodegenerative disorders associated with extracellular protein deposition.