Sibling recurrence risk in autoimmune thyroid disease
Sibling recurrence risk in autoimmune thyroid disease
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DOI：
10.1089/105072503768499653
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发表时间：
2003-08-01
期刊：
影响因子：
6.6
通讯作者：
Tomer, Y
中科院分区：
文献类型：
--
作者：
Villanueva, R;Greenberg, DA;Tomer, Y
有大量的证据表明遗传因素对自身免疫性甲状腺疾病（AITD）的发展有影响。一种衡量遗传因素对疾病发展的影响程度的方法是同胞风险比（As）。美国国家健康和营养调查III（NHANES 111）研究报告的最近甲状腺功能减退症和甲状腺功能亢进症的准确患病率数据现在允许我们计算AITD的同胞复发风险。患者从我们的内分泌诊所招募的基础上有AITD。本研究纳入的患者是明确的单一确定。我们研究了155例患者（131例Graves病[GD]和24例桥本甲状腺炎[HT]），这些患者具有兄弟姐妹中存在或不存在AITD的可靠信息。9名先证者有GD兄弟姐妹，13名先证者有HT兄弟姐妹。使用NHANES III中临床甲状腺功能亢进症和甲状腺功能减退症的患病率，计算出的AITD的λ为16.9，GD为11.6，HT为28.0。这些结果证实了遗传因素对AITD发展的重要作用。
There is abundant evidence for a genetic influence on the development of autoimmune thyroid diseases (AITD). One measure of the magnitude of genetic contribution to the development of a disease is the sibling risk ratio (As). Recent accurate prevalence data for hypothyroidism and hyperthyroidism in the United States reported from the National Health and Nutrition Examination Survey III (NHANES 111) study have now allowed us to compute the sibling recurrence risk for AITD. Patients were recruited from our endocrine clinic on the basis of having AITD. The inclusion of patients in this study was unambiguously single ascertainment. We studied 155 patients (131 with Graves' disease [GD] and 24 with Hashimoto's thyroiditis [HT]) who had reliable information on the presence or absence of AITD in siblings. Nine probands had siblings with GD and 13 probands had siblings with HT. Using the prevalence rates from NHANES III for clinical hyperthyroidism and hypothyroidism, the calculated lambda(s) was 16.9 for AITD, 11.6 for GD, and 28.0 for HT. These results confirm the significant contribution of genetic factors to the development of AITD.