Transient patterns of cortical lamination during prenatal life: Do they have implications for treatment?
Transient patterns of cortical lamination during prenatal life: Do they have implications for treatment?
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DOI：
10.1016/j.neubiorev.2007.04.018
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发表时间：
2007-01-01
影响因子：
8.2
通讯作者：
Judas, Milos
中科院分区：
文献类型：
--
作者：
Kostovic, Ivica;Judas, Milos
含有电路元件（突触、突触后神经元和突触前轴突）的瞬时板层从第8周开始出现在脑壁中，并在出生后第6个月后随着基板区的消退而消失。第一个内源性突触回路在皮质板的上面和下面的两个板层中发展。胎儿中期和晚期（15-23 PCW）显示出分层模式，具有含有GABA能、谷氨酸能和肽能神经元、突触和丘脑皮质传入神经的厚亚板区，这些神经元在21 - 23 PCW之间的浅亚板区等待和积累，这些标志着区域边界。在早产儿中，一些丘脑皮质纤维重新定位到视觉，躯体感觉，听觉和联想皮层的皮质板，形成一个框架的感觉驱动的连接，而其他仍然从事内源性subplate区电路。皮质-皮质通路继续增长。在新生儿期，胼胝体投射和短皮质连接、树突棘和突触的发育有重大重组。总之，瞬态神经元回路的基础上的瞬态功能在胎儿，围产期和出生后早期的生活，并决定发育可塑性的大脑皮层和温和的影响，病变的发育中的大脑。(c)2007爱思唯尔有限公司版权所有。
Transient laminae containing circuitry elements (synapses, postsynaptic neurons and presynaptic axons) appear in the cerebral wall from the eighth postconceptional week (PCW) and disappear with the resolution of the subplate zone after the sixth postnatal month. The first endogeneous synaptic circuitry develops in two laminae, above and below the cortical plate. Mid- and late fetal period (15-23 PCW) shows lamination pattern with a thick subplate zone containing GABAergic, glutamatergic and peptidergic neurons, synapses and thalamocortical afferents which are waiting and accumulating in the superficial subplate zone between 21 and 23 PCW and these mark regional boundaries. In preterm infants, some thalamocortical fibers relocate to the cortical plate in visual, somatosensory, auditory and associative cortices, forming a framework for sensory-driven connectivity, while other remain engaged in the endogeneous subplate zone circuitry. Corticocortical pathways continue to grow. In the neonatal period, there is a major reorganization of callosal projections and development of short corticocortical connections, dendritic spines and synapses. In conclusion, transient neuronal circuitry underlies transient functions during the fetal, perinatal and early postnatal life and determines developmental plasticity of the cerebral cortex and moderates effects of lesion of the developing brain. (c) 2007 Elsevier Ltd. All rights reserved.