Aging, Male Sex, Obesity, and Metabolic Inflammation Create the Perfect Storm for COVID-19
Aging, Male Sex, Obesity, and Metabolic Inflammation Create the Perfect Storm for COVID-19
复制标题
衰老、男性性别、肥胖和代谢性炎症为 COVID-19 创造了完美风暴
DOI：
10.2337/dbi19-0023
复制
发表时间：
2020-09-01
期刊：
影响因子：
7.7
通讯作者：
Mauvais-Jarvis, Franck
中科院分区：
文献类型：
--
作者：
Mauvais-Jarvis, Franck
2019年冠状病毒病（COVID-19）是一种新型威胁，似乎是由新的严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）大流行和肥胖驱动的现有代谢性疾病大流行之间的勾结造成的。该观点探讨了不断发展的流行病学，临床，生物学和分子证据，提出了一个展开的范式，其中老年，慢性代谢疾病（如肥胖，2型糖尿病和代谢综合征）和男性生物性别产生了一种致命的免疫代谢失调和慢性全身炎症的共生关系，加剧了与SARS-CoV-2感染相关的病毒诱导的过度炎症。它旨在激发新的研究方向，并刺激在这一领域的资金。
Coronavirus disease 2019 (COVID-19) is a novel threat that seems to result from the collusion between a new pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and an existing pandemic of metabolic disease driven by obesity. This Perspective explores the evolving epidemiological, clinical, biological, and molecular evidence to propose an unfolding paradigm in which old age, chronic metabolic disease (such as obesity, type 2 diabetes, and metabolic syndrome), and male biological sex produce a deadly symbiosis of dysregulated immunometabolism and chronic systemic inflammation that intensifies virally induced hyperinflammation associated with SARS-CoV-2 infection. It is intended to inspire new research directions and stimulate funding in this field.