Enhanced humoral and Type 1 cellular immune responses with Fluzone® adjuvanted with a synthetic TLR4 agonist formulated in an emulsion
Enhanced humoral and Type 1 cellular immune responses with Fluzone® adjuvanted with a synthetic TLR4 agonist formulated in an emulsion
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DOI：
10.1016/j.vaccine.2009.07.081
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发表时间：
2009-10-09
期刊：
影响因子：
5.5
通讯作者：
Reed, Steven G.
中科院分区：
文献类型：
--
作者：
Baldwin, Susan L.;Shaverdian, Narek;Reed, Steven G.
抗流感辅助性T细胞1（Th 1）反应受损与老年人流感相关死亡风险增加相关。在现有的流感疫苗中添加佐剂可以提高老年人的免疫反应。在这项研究中，活性的三种佐剂，水包油乳剂和合成的脂质A佐剂配制或没有乳剂，进行了比较。我们的研究结果表明，Fluzone与脂质A加乳剂的组合有效地导致更大的疫苗特异性IgG 2a和IgG滴度，增强血凝抑制滴度，并诱导1型细胞因子应答（IFN-γ和IL-2）。(C)2009爱思唯尔有限公司保留所有权利。
Impairments in anti-influenza T helper 1 (Th1) responses are associated with greater risk of influenza-related mortality in the elderly. Addition of adjuvants to existing influenza vaccines could improve immune responses in the elderly. In this study, the activity of three adjuvants, an oil-in-water emulsion and a synthetic lipid A adjuvant formulated with or without the emulsion, is compared. Our results show that Fluzone combined with lipid A plus an emulsion effectively leads to greater vaccine-specific IgG2a and IgG titers, enhances hemagglutination-inhibition titers and induces Type 1 cytokine responses (IFN-gamma and IL-2) to each of the Fluzone components. (C) 2009 Elsevier Ltd. All rights reserved.