In vivo evaluation of a novel alginate dressing.
In vivo evaluation of a novel alginate dressing.
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DOI：
10.1002/(sici)1097-4636(1999)48:4
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
Yoshihisa Suzuki;M. Tanihara;Yoshihiko Nishimura;Kyoko Suzuki;Yoshio Yamawaki;Hitoshi Kudo;Y. Kakimaru;Yasuhiko Shimizu
中科院分区：
文献类型：
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作者：
Yoshihisa Suzuki;M. Tanihara;Yoshihiko Nishimura;Kyoko Suzuki;Yoshio Yamawaki;Hitoshi Kudo;Y. Kakimaru;Yasuhiko Shimizu
藻酸盐敷料目前用于表皮和真皮伤口的管理，并提供导致快速肉芽形成和上皮再生的潮湿环境。然而，最近已经报道了对成纤维细胞增殖和愈合伤口中的炎症残留物质的细胞毒性作用。我们开发了一种新的藻酸盐敷料（阿加-100），它对成纤维细胞的增殖没有抑制作用。本研究旨在评价新型藻酸盐敷料在全层和部分厚度猪伤口中的伤口愈合情况以及植入家兔肌肉后的生物降解情况。Kaltostat和Sorbsan（均为成熟的市售敷料）用作对照。与Kaltostat和Sorbsan相比，用阿加-100治疗的全层伤口的闭合率在第15天显著更高。在第3天，Sorbsan治疗的部分厚度伤口的上皮再生率在统计学上显著低于其他两种敷料。至于愈合伤口中残留的敷料碎片，在所有使用Kaltostat或Sorbsan治疗的全层伤口中观察到大量异物碎片，而使用阿加-100治疗的伤口中仅约三分之一显示出少量敷料碎片。阿加-100植入家兔肌肉内3个月内完全被生物吸收。因此，阿加-100治疗的全层伤口中的敷料残留物可能在几个月内被完全吸收。综上所述，我们新开发的阿加-100敷料与典型的海藻酸盐敷料相比具有上级性能。
Alginate dressings are currently used in the management of epidermal and dermal wounds, and provide a moist environment that leads to rapid granulation and reepithelialization. However, a cytotoxic effect on proliferation of fibroblasts and residual material with inflammation in healing wounds have been reported recently. We have developed a new alginate dressing (AGA-100), which does not have an inhibitory effect on proliferation of fibroblasts. The purpose of this study was to evaluate the new alginate dressing with respect to wound healing in full- and partial-thickness pig wounds and with respect to biodegradation following implantation into rabbit muscle. Kaltostat and Sorbsan, both well-established commercial dressings, were used as control. The closure rate of full-thickness wounds treated with AGA-100 was significantly higher on day 15 compared with that with Kaltostat and Sorbsan. Reepithelialization rate of partial-thickness wounds treated with Sorbsan was statistically significantly lower on day 3 than those with the other two dressings. As to dressing debris remained in the healing wound, a large amount of foreign debris was noted in all the full-thickness wounds treated with Kaltostat or Sorbsan, while only about one-third of wounds treated with AGA-100 showed a little dressing debris. AGA-100 implanted into the muscle of rabbits was bioresorbed completely within 3 months. Therefore, dressing residue in AGA-100-treated full-thickness wounds might be fully absorbed in a few months. In conclusion, it is shown that our newly developed AGA-100 possesses superior properties compared with typical alginate dressings.