POST‐ISCHEMIC CHANGES IN CERTAIN METABOLITES FOLLOWING PROLONGED ISCHEMIA IN THE GERBIL CEREBRAL CORTEX
POST‐ISCHEMIC CHANGES IN CERTAIN METABOLITES FOLLOWING PROLONGED ISCHEMIA IN THE GERBIL CEREBRAL CORTEX
复制标题
沙鼠大脑皮层长期缺血后某些代谢物的缺血后变化
DOI：
10.1111/j.1471-4159.1976.tb06992.x
复制
发表时间：
1976
影响因子：
4.7
通讯作者：
I. Klatzo
中科院分区：
文献类型：
--
作者：
B. Mršulja;W. Lust;B. Mršulja;J. Passonneau;I. Klatzo
- 在沙土鼠大脑皮层单侧缺血1或3小时后的缺血后阶段测量了8种代谢物。缺血后1 h，ATP、P-肌酸、葡萄糖、糖原和GABA水平基本恢复。缺血3 h组。在再循环5和20小时后糖原继续增加至大于对照值。缺血期间谷氨酸的浓度没有变化，但在Smin和缺血后1小时下降至对照组的60%。环腺苷酸的浓度在缺血期间升高4至5倍。在两组中，再循环后5分钟增加了6倍。恢复后1小时。水平与对照值没有差异。1小时缺血期后，乳酸水平恢复之间的5和20小时的再循环。缺血3 h组。即使在再循环20小时后，乳酸盐浓度仍然升高。这些数据表明，除了乳酸盐。代谢物的恢复不会被1或3小时的缺血严重损害。此外，糖原的变化。再循环后谷氨酸和环AMP的变化表明，恢复过程不仅仅是缺血期间观察到的变化的恢复。
‐Eight metabolites were measured in the post‐ischemic period following either 1 or 3 h of unilateral ischemia in the gerbil cerebral cortex. The levels of ATP, P‐creatine, glucose, glycogen and GABA were essentially restored by 1 h after ischemia. In the 3 h ischemic animals. glycogen continued to increase to greater than control values aftcr 5 and 20 h of recirculation. The Icvels of glutamate were unchanged during the ischemic episode, but decreased to 60% of control at Smin and 1 h after either period of ischemia. The concentrations of cyclic AMP, which were 4‐to 5‐fold elevated during ischemia. increased an additional 6‐fold 5 min after recirculation in both groups. Arter 1 h of recovery. the levels were not different from control values. After the 1 h ischemic period, lactate levels recovered between 5 and 20 h of recirculation. In the 3 h ischemic animals. lactate concentrations were still elevated even after 20 h of recirculation. These data suggest that with the exception of lactate. recovery of metabolites is not sevcrely compromiscd by either 1 or 3 h of ischemia. Furthermore, the changes in glycogen. glutamate and cyclic AMP after recirculation suggest that the recovery process is not just a rcversal of the changes observed during ischemia.