Age-specific serum anti-Mullerian hormone values for 17,120 women presenting to fertility centers within the United States
Age-specific serum anti-Mullerian hormone values for 17,120 women presenting to fertility centers within the United States
复制标题
DOI：
10.1016/j.fertnstert.2010.10.011
复制
发表时间：
2011-02-01
影响因子：
6.7
通讯作者：
Leader, Benjamin
中科院分区：
文献类型：
--
作者：
Seifer, David B.;Baker, Valerie L.;Leader, Benjamin
目的：为确定在美国生育诊所就诊的妇女的年龄特异性血清抗苗勒管激素（AMH）值。设计：回顾性研究。设置：单一临床参考实验室。患者：总计17，120名育龄妇女，年龄范围从24岁到50岁。干预：无。主要结果测量：确定单年AMH中位数和平均值及SD。结果：单年特定中位数、平均值和SD值总结见表1。AMH的中位数和平均值均以与年龄增长高度相关的方式稳步下降。在35岁之前，血清AMH中位值的平均年下降率为0.2 ng/mL/年，然后在35岁之后下降至0.1 ng/mL/年。平均AMH值的下降率为0.2 ng/mL/year，到40岁，然后减少到0.1 ng/mL/yearfollow. Conclusions（s）：中位数和平均AMH水平随着年龄的增加而稳定下降，从24岁到50岁。这些数据可能对正在考虑生殖选择的医生及其患者有价值。（Fertil Steril（R）2011;95：747-50. (C)美国生殖医学会（American Society for Reproductive Medicine）
Objective: To determine age-specific serum anti-Mullerian hormone (AMH) values for women presenting to U.S. fertility clinics.Design: Retrospective study.Setting: Single clinical reference laboratory.Patient(s): A total of 17,120 women of reproductive age ranging from 24 to 50 years old.Intervention(s): None.Main Outcome Measure(s): Determination of single-year median and mean AMH values with SDs.Result(s): Single-year-specific median, mean, and SD values are summarized in Table 1. Both median and mean AMH values decreased steadily in a manner highly correlated with advancing age. The average yearly decrease in the median serum AMH value was 0.2 ng/mL/year through age 35 and then diminished to 0.1 ng/mL/year after age 35. The rate of decline in mean AMH values was 0.2 ng/mL/year through age 40 and then diminished to 0.1 ng/mL/year thereafter.Conclusion(s): Median and mean AMH levels decreased steadily with increasing age from 24 to 50 years of age. Such data may be of value to physicians and their patients who are considering reproductive options. (Fertil Steril(R) 2011;95:747-50. (C) 2011 by American Society for Reproductive Medicine.)